Neuroepithelial bodies

There are some indications that mammals possess at least two H2O2 sensors. One is located in cells of the lung neuroepithelial bodies, being responsible for constriction of the lung airways when the H2O2 level rises [6,7]. The other performs the same function in the blood vessels, being found in cells of the carotid body [8-10]. 

Neuroepithelial bodies found in mammalian airways have oxygen-sensitive K currents and are putative airway chemoreceptors that detect changes in the level of O2 in the airway lumen (Wang et al.,... 

Fu XW, Nurse CA, Wong V, Cutz E. 2002. Hypoxia-induced secretion of serotonin from intact pulmonary neuroepithelial bodies in neonatal rabbit. J Physiol 539 503-510. 

Lauweryns JM, de Bock V, Decramer M. 1987. Effects of unilateral vagal stimulation on intrapulmonary neuroepithelial bodies, J Appl Physiol 63 1781-1787. 

Brouns I, Pintelon I, De Proost I, Alewaters R, Timmermans JP, Adriaensen D (2006) Neurochemical characterisation of sensory receptors in airway smooth muscle comparison with pulmonary neuroepithelial bodies. Histochem CeU Biol 125(4) 351-67 Brozmanova M, Plevkova J, Bartos V, Plank L, Tatar M (2005) Antileukotriene treatment and allergic rhinitis-related cough in guinea pigs. J Physiol Pharmacol 56 (Suppl 4) 21-30 Burki NK, Dale WJ, Lee LY (2005) Intravenous adenosine and dyspnea in humans. J Appl Physiol 98(1) 180-5... 

After naphthalene (300 mg/kg i.p.) treatment of mice and epithelial repair, neuroepithelial bodies were significantly increased along the walls of the airways as well as on branch point ridges (Peake et al. 2000). Reynolds et al. (2000) provided the following evidence that the neuroepithelial body microenvironment serves as a source of airway progenitor cells that contribute for focal regeneration of the airway epithelium ... 

Cutz E, Jackson A. Neuroepithelial bodies as airway oxygen sensors. Respir Physiol 1999 115 201-214. 

Lauweryns JM, Cokeleare M. H3fpoxia sensitive neuroepithelial bodies intrapulmonary secretory neuroreceptors, modulated by CNS. Z ZeUforsch Mikrosk Anat 1973 145 521-540. 

Youngson C, Nurse, Yeger H, Cutz E. Characterization of membrane currents in pulmonary neuroepithelial bodies hypoxia-sensitive airway chemoreceptors. In O Regan RG, Nolan P, McQueen DS, Paterson DJ, eds. Arterial Chemoreceptors. Cell to System. New York and London Plenum Press, 1994 179-182. 

The mechanism of acute O2 sensing based on the regulation of membrane K" " channels seems to be a rather general phenomenon that has been shown to operate in other neurosecretory systems, such as the cells in the neuroepithelial bodies of the Ixmg (18), chromaffin cells of the adrenal medulla (19), or PC 12 cells... 

Oxygen Sensing in Puimonary Neuroepithelial Bodies and Related Tumor Cell Model... 

Lauweryns JM, Cokelaere M, Theunuyck P. Neuroepithelial bodies in mammalian respiratory mucosa of various mammals light optical, histochemical and ultrastmctural investigation. Z Zellforsch 1972 135 569-592. 

Sorokin SP, Hoyt RF. Neuroepithelial bodies and solitary small-granule cells. In Massaro D, ed. Lung Cell Biology. New York Marcel Dekker, 1989 191-344. 

Lauweryns JM, Cokelaere M. Hypoxia sensitive neuroepithelial bodies, intrapuhnon-ary secretory neuroreceptors undulated by the CNS. Z Zellforsch 1973 145 521-540. 

Lauweryns JM, Cokelaere M, Lerut T. Cross-circulation studies on the influence of hypoxia and hypoxaemia on neuroepithelial bodies in young rabbits. Cell Tissue Res 1978 193 373-386. 

Cutz E, Speirs y Yeger H, Newman C, Wang D, Perrin DG. Cell biology of pulmonary neuroepithelial bodies— validation of an in vitro model. Anat Reo 1993 236 41-52. 

Van Lommel A, Lauweryns JM, Berthoud HR. Pulmonary neuroepithelial bodies are innervated by vagal afferent nerves an investigation with in vitro antergrade Dil tracing and confocal microscopy. Anat Embryol 1998 197 325-330. 

O Kelly I, Stephens RH, Peers C, Kemp PJ. Potential identification of the 02-sensitive K+ current in human neuroepithelial body-derived cell line. Am J Physiol 1999 276 L96-L104. 

Cutz E, Chan W, Sonstegard K. Identification of neuroepithelial bodies in rabbit fetal lungs by scanning electron microscopy a correlative light, transmission and scanning electron microscopic study. Anat Rec 1978 192 459-466. 

Hung KS, Chapman AL, Mestermacher MA. Scanning electron microscopy of bron-chiolar neuroepithelial bodies in neonatal mouse lungs. Anat Rec 1979 193 913—926. 

Lauweryns JM, Van Lommel A, Dom RJ. Innervation of rabbit intrapulmonaiy neuroepithelial bodies quantitative and qualitative ultrastructural study after vagotomy. J Neurol Sci 1985 65 81-92. 

Yeger H, Pan J, Fu XW, Bear C, Cutz E. Expressions of CFTR and Cl-conductances in pulmonary neuroepithelial bodies. Am J Physiol 2001 281 L713-L721. 

Lauweryns JM, Van Ranst L. Protein gene product 9.5 expression in lungs of human and other mammals. Iimnunohistochemical detection in neuroepithelial bodies, neuroendocrine cells and nerves. Neurosci Lett 1988 85 311-316. 

Lauweryns JM, Van Ranst L. Leu-7 like inmiunoreactivily in human, monkey and pig bronchopulmonary neuroepithelial bodies and neuroendocame cells. J Histochem Cytochem 1987 35 687-691. 

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