Neurodegenerative disease multiple sclerosis

Parkinson s disease together with Alzheimer s disease, multiple sclerosis, Huntington s disease, and amyotrophic lateral sclerosis belongs to a group of neurodegenerative diseases for which the pharmacological treatments are mostly symptomatic. 

CXCR3 is expressed in the immnne system as two isoforms, CXCR3-A and CXCR3-B. It is an important chemokine receptor associated with varions inflammatory neurodegenerative diseases (e.g. multiple sclerosis) and other models of nenronal injury as reviewed by (Liu et al. 2005). 

Neurodegenerative diseases, for example, early ageing, dementia of Alzheimer type, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, and Parkinson Disease. 

For neuropharmaceuticals that target the brain, as in the cases of neurodegenerative disorders (Alzheimer s, multiple sclerosis),psychiatric or psychotherapy, stroke, and infectious diseases, drug candidates are tested using in vivo and in vitro models to assess the transfer of the drug compound across the BBB. 

Similar to opioids, the cannabinoid system appears to be intricately involved in normal physiology, specifically in the control of movement, formation of memories, and appetite control. Basic research has discovered that members of this family of compounds have the capacity to protect threatened neurons, thereby slowing neurodegenerative processes that ultimately lead to physical disability. As the function of the physiological role of endocannabinoids becomes clearer, it appears the system may be involved in the pathology of several neurological diseases, specifically multiple sclerosis, spasticity, and pain. In 1999 the German journal, Forschende Komplementar-medizin und Klassische Naturheilkunde (Research in Complementary and Classical Natural Medicine) commented ... 

Tlie genetics underlying multiple sclerosis are typical for a neurodegenerative disease in that... 

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