Neuro AIDS

Efflux of Neuro AIDS-related Proteins and Cytokines... 

Arendt G, von Giesen HI (2002) Antiretro viral tlierapy regimens for neuro-AIDS. Current Drug Targets—hifectious Disorders 2 187-192. 

Enzensberger W, von Giesen HJ (1999) Andretroviral dierapy (ART) from a neru ological point of view. German Neuro-AIDS study group (DNAA). Eru J Med Res 22 456-462. 

TNF-a is released from virtually all brain parenchymal cells after trauma, hypoxia, epilepsy, neuro-AIDS, and inflammation [73]. Interestingly, TNF-a is not only specifically transported across the BBB but also modulates the functions of the specialized endothelial cells lining the BBB [74—76]. TNF-a transport across the BBB follows a circadian rhythm, and strikingly ABCBl expression at the BBB also displays a circadian rhythm [71, 77]. Upon receptor binding, TNF-a probably affects ABCBl expression by activating NFkB, which binds to the proximal promoter of ABCBl and activates its transcription [78]. 

Taken together, these results underline the important role of inflammation at the BBB. As the BBB is a natural barrier that shields the brain from potentially noxious substances, inflammatory mediators such as TNF-a may serve as potentiators of BBB s barrier function. Unfortunately, the increased barrier function also shields the brain from treatment when the inflammatory signal originates from within the brain. These considerations lead us to suggest the coadministration of antiinflammatory agents in brain disease states with an inflammatory component (e.g., neuro-AIDS). 

Intended for the treatment of HIV/AIDS, cancer, diabetes, or neuro-degenerative disorders... 

Aging (skin and other tissues), myocardial infarct or stroke, inflammation, rheumatoid arthritis, atherosclerosis, pulmonary disorders (asthma and chronic obstructive pulmonary diseases), radiation injury, organ transplant rejection, psoriasis, hypertension, AIDS, multiple types of cancer, neuro-degenerative diseases (Parkinson s), diabetes, muscular dystrophy... 

For this reason, apoptosis can play a critical role in many pathological conditions. It is well known that a balance between cell death and cell proliferation is essential for maintaining a cellular homeostatic state. Deviation from this cellular balance can lead to human disease thus, for example, cell accumulation due to insufficient apoptosis can contribute not only to cancer, but also to inflammations such as rheumatoid arthritis, as well as to autoimmune diseases such as lupus and lupus-like syndromes. On the other hand, excessive apoptosis may play an important role in neuro degeneration, acquired immunodeficiency syndrome (AIDS), osteoporosis, and heart failure. A fuller understanding of this complex physiological process of cell death would therefore be of great benefit in maintaining human health [3,4],... 

H. I. Krebs, B. T. Volpe, M. L. Aisen, and N. Hogan (2(X)0), Increasing productivity and quality of cate Robot-aided neuro-rehabilitation. Journal of Rehabilitation Research and Development 37 639-652. 

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