Neural glial cell adhesion molecule

NF-xB Nuclear fector-xB NgCAM Neural-glial cell adhesion molecule... 

Cell adhesion molecules (CAMs) play critical roles in all facets of nervous system development and maintenance. Important phenomena in which CAMs are involved include initial formation of the neural tube and the neural crest, migration of all neurons and glial cells, axonal outgrowth and guidance, target selection, synaptic stabilization and plasticity, myelination and nerve regeneration after injury (see Chs 4,24,28-30 and 53). Adhesion molecules interact with each other and with nonadhesive cell-surface and/or cytoplasmic molecules, and, in the two... 

CD56 (also known as neural cell adhesion molecule) is expressed on the cell surface of a number of different tissues including natural killer cells, glial and neurons. This antigen may be demonstrated on monocytic and myeloid leukemias, plasma cell dyscrasias, natural killer cell lesions, neural and astrocytic tumors as well as tumors with neuroendocrine differentiation. Antigen density on hematopoietic tumors tends to be at a lower level than on non-hematopoietic lesions and the validation with flow cytometry determination for this antigen is recommended. 

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