Nerve growth factor cell specificity

Inoue N, Hatanaka H. Nerve growth factor induces specific enkephalin binding sites in a nerve cell line. J Biol Chem 1982 257 9238-9241. 

Glickman, M., Malek, R.L., Kwitek-Black, A.E., Jacob, H.J. and Lee, N.H., 1999, Molecular cloning, tissue-specific expression, and chromosomal localization of a novel nerve growth factor-regulated G-protein-coupled receptor, nrg-1, Mol. Cell. Neurosci. 14 141-152. 

D. J., and Don, K.-W., Structure of the gene encoding VGF, a nervous system-specific mRNA that is rapidly and selectively induced by nerve growth factor in PC12 cells. Mol. Cell Biol. 11, 2335-2349, 1991. 

As a quantitatively measurable specific function of glial cells, the rate of synthesis of three neurotrophic factors (nerve growth factor [NGF] brain-derived neurotrophic factor [BDNF] and glial cell line-derived neurotrophic factor [GDNF]) was measured. In the Ohta et al. (2002) study, the enhancer effect of (-)-BPAP was measured only in the high concentration range. The authors found the amount of NGF, BDNF, and GDNF secreted from astrocytes into the culture medium increased by up to 120,2, and 7 times more, respectively, than those of the control treatment with 0.35 mM (-)-BPAP for 24 h. The (-)-BPAP-... 

P75 nerve growth factor-receptor protein (NGF-R) is present in developing and adult Purkinje cells. Yan and Johnson (1988) and Cohen-Cory et ah (1989) described and reviewed the development of NGF-R in rat cerebellum. Low affinity NGF-R immunoreactivity has been demonstrated with species-specific monoclonal antibodies in Purkinje cells of adult rats (Pioro and Cuello, 1988, 1990 Pioro et ah, 1991 Fusco et ah, 1991 Dusart et ah, 1994), monkey and human brain (Mufson et ah, 1991). Immunoreactivity was present in the somata, dendrites and the proximal axon of the Purkinje cells. Additional immunoreactivity in granule cells was reported by Vega et ah... 

The epitopes recognized by Hawkes family of monoclonal antibodies known as the anti-Zebrins are localized on Purkinje cells (see Section 3.1.8.). Zonal patterns that are identical or very similar to Zebrin I and II have been described for the distribution of 5 -nucleotidase (see above), the p75 low affinity nerve growth factor receptor protein in the rat (Section 3.1.10., Fig. 38), protein kinase C delta (Fig. 133) (see Section 3.1.5.) and the B30 antibody of Stainier and Gilbert (1989) (see Section 3.1.8.). Immunoreactiv-ity in mouse Purkinje cells for an antibody against HNK is partially congruent with the Zebrin negative Purkinje cells, but Zebrin+/HNK-l- Purkinje cells also exist (Hawkes, 1992 Eisenman and Hawkes, 1993). The similarity between the Zebrin pattern and the transient zonal patterns in the development of the Purkinje cell specific marker L7 is discussed in Section 6.2. 

Sarcomatoid melanomas are consistently SIOOP positive, but only 3% to 10% can be labeled for other, more specific melanocytic determinants (Fig. 7.16). °420,121,123,192 Because a proportion of such lesions becomes transmogrified into spindle-cell proliferations with divergent phenotypes, immunoreactivity for CD56, CD57, nerve growth factor receptor, desmin, and actin isoforms is potentially observed in them (Figs. 

The continued availability of adequate trophic support appears to be crucial not only for the development of nerve cells and their interconnecting circuitry, but also for the maintenance of neurons and their synapses in the adult (31). There is considerable evidence that diffusible, target-derived trophic factors play important roles in the development of specific retinal cell types. In particular, the neurotrophins [nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin (NT)-3 and NT-4/5] have received considerable attention for their potential roles in both developing and adult nervous systems (66,67). 

Studies on the effect of ERK and JNK activation on cellular outcome have revealed that the consequence of this activation is cell type specific. While the activation of ERBCs is often proliferative in nature, it may not always be so. For example, the induction of ERK by nerve growth factor in PC12 cells leads to terminal differentiation and exit from the cell cycle [80]. In other cell types, the ability of the cell to survive an insult is often dependent on the balance between ERK and JNK... 

Cell-specific and developmental regulation of a nerve growth factor-human growth hormone fusion gene in transgenic mice. Neuron 3 133-139. 

Matsuoka, I., Meyer, M. and Thoenen, H. (1991) Cell-type-specific regulation of nerve growth factor (NGF) synthesis in non-neuronal cells comparison of Schwann cells with other cell types. 7. Neurosci. 11 3165-3177. 

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