Necrosis single-cell

Single-cell necrosis Single-cell necrosis (s. pp 400, 545) becomes manifest as the destruction of fatty liver cells and as hyaline necrosis. The latter is either drained haematogenically or removed by stellate cells, which may generate stellate cell nodules. When disposing of fatty liver cells, the stellate cells take in lipoid from the necrotic epithelium and become foam-like. This may result in the formation of lipophagic granulomas, (s. p. 398) However, leucocytes also participate, sometimes even exclusively, in the removal of fatty hepatocytes. 

D4. Didenko, V. V., and Hornsby, P. J., Presence of double-strand breaks with single-base 3 overhangs in cells undergoing apoptosis but not necrosis. J. Cell Biol. 135, 1369—1376 (1996). 

Fig. 21.1 Non-specific reactive hepatitis in sepsis due to cervical l)mph node abscess sparse single cell necrosis and periportal inflammation...

Single-cell necrosis Necrotic hepatocytes are found both as groups and in isolation. Initially, they either form small patches or are disseminated throughout the liver. The reticular fibres at first remain, but are later removed. 

Liver cell degenerations (hydropic swelling, eosinophilic degeneration, pin cells, hyaline bodies) and cell polymorphy, single cell necrosis in the form of (acidophilic) Councilman bodies, infiltration of lymphocytes, macrophages and activated stellate cells (yet only few plasma cells and neutrophilic granulocytes), proliferation of sinusoidal cells. 

Hyaline single cell necrosis (rather similar in appearance to Councilman bodies) is nearly always witnessed. This cell necrosis is the result of cytotoxicity, mediated by T lymphocytes. 

Fig. 23.1 Agglomeration of activated Kupffer cells (partially beaded), especially in the sinusoidal vessels, with single-cell necrosis. Clinical diagnosis hepatitis mononucleosa (HE)...

Fig. 29.15 Chronic toxic hepatitis after 10 months chaparral ( creosote bush ) automedication. Laparoscopy marked acinar structure, irregular chagreen-like surface (splintered light reflex) and extremely fine fibrosis histology single cell necrosis, slight inflammatory infiltrations and moderate steatosis...

Polymyositis can occur as a primary disease or a paraneoplastic syndrome. Clinically, there is weakness and pain in the shoulder and hip musculature, with muscular atrophy. Laboratory parameters show greatly elevated inflammatory criteria (s. tab. 38.2) as well as a rise in myosin AB. Liver involvement is characterized by hepatomegaly, inflammatory infiltration of the portal fields, fatty changes in the liver cells and single-cell necrosis as well as necrotic foci. 

The single-cell imaging on microfluidic device helps to quantitatively monitor intracellular sodium ion (Na+) concentration, potassium channel permeability, and apoptosis or necrosis and thus provides an advantage over the patch clamp system [58], The inhibition of potassium channels is monitored by using the FluxOR thallium detection kit. FluxOR dye is cleaved by endogenous esterases to thallium-sensitive fluorescent indicator inside the cells, and... 

Hepatic Effects. A single case study reported areas of focal necrosis and cell degeneration in the liver of a worker exposed to an undetermined concentration of hydrazine in air once a week for 6 months (Sotaniemi et al. 1971). Studies of workers exposed to 1,1-dimethylhydrazine have reported changes indicative of a hepatic effect including elevated scrum alanine aminotransferase activity, fatty degeneration, and a positive cephalin flocculation test (Petersen et al. 1970 Shook and Cowart 1957). Although the levels of hydrazine and 1,1-dimethylhydrazine exposure were not determined, these studies indicate qualitatively that tlie liver is a target for both hydrazines. 

Histologically, BSCC has a biphasic appearance, where the basaloid component usually dominates. The second component of a conventional SCC is usually only minor and can even be quite focal." BSCC usually grows in smooth contoured lobules, large nests, or trabecular cordlike arrangements of small clusters or even single cells. The lobules often contain central comedo-type necrosis. Cystic spaces and even abortive ductal differentiation can be present in a minority of the tumors. Very rarely the tumor can have deposition... 

Microscopically, small cell neuroendocrine carcinomas are identical to their pulmonary counterparts and, as such, are composed primarily of round to short spindle cells with sparse, poorly defined cytoplasm and hyperchromatic nuclei without nucleoli. Nuclear molding, frequent mitoses, necrosis, and single-cell apoptosis are common. 

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