Fatty degeneration

Steatosis A process of tissue degeneration characterized by deposition of fat globules in cells also known fatty degeneration. 

The liver is sensitive to hexachloroethane following both acute and longer term exposure scenarios. Evidence of effects on the liver include increased weight and centrilobular necrosis in rats and rabbits and increased serum levels of liver enzymes in sheep. There can also be fatty degeneration of the tissues and hemorrhage when damage is severe. 

Systemic Rabbit (NS) 19-70 x total, 5 d/wk 2 hr/d Hepatic Renal Dermal 67-91 F 20-42 F (fatty degeneration) 20-42 F (degenerative changes) Treon etal. 1955 Endrin... 

Intermediate-duration inhalation studies were all single concentration studies at concentrations that resulted in serious effects (26-52 ppm) (Deichmann et al. 1944), or no effects (5 ppm) (Sandage 1961). Therefore, an intermediate-duration inhalation MRL was not derived for phenol. The serious effects noted included pneumonia, necrosis of the myocardium, fatty degeneration of the liver, glomerular degeneration, and hindlimb paralysis (Deichmann et al. 1944). Additional inhalation studies that... 

Fig. 29. Thirteen-year-old boy with Duchenne Dystrophy, (a) The fat selective image shows a fatty degeneration of all muscles in a cross-section of the lower limb. The fat tissue is orientated in the direction of the muscle fibres, and is present between the fibres and in the septa, (b, c) The spectra from both volume elements indicated in (a) reveal signals from EMCL. Muscle specific metabolites (TMA and creatine) are clearly reduced and not visible in the proton spectra due to the reduction of muscle tissue in favour of adipose tissue.

Fig. 30. Thirteen-year-old boy with desmin storage myopathy, (a) The T weighted image shows an atrophy of the tibialis anterior muscle (with the volume element indicated) and a fatty degeneration of the soleus muscle (arrow), (b) The spectrum from the tibialis anterior muscle shows prominent EMCL. TMA is reduced as indicated in the area of the 5-fold magnification.

Fig. 31. Twenty-year-old woman with glutaric aciduria type I. (a) The Ti weighted image shows normal findings for the cross-section of the lower limb. The volume element for spectroscopy was chosen in the soleus muscle, (b) The 7-fold magnification depicts a reduction of TMA. Although no fatty degeneration is visible on the image, the spectrum is dominated by EMCL.

No studies were located regarding hepatic effects in animals after dermal exposure to 1,3,5-TNB. In one of the earliest studies with 1,3-DNB, the investigators indicate that necropsy of a cat (1 out of 3) to which an ointment containing 25% (w/w) 1,3-DNB was applied 8 days earlier showed fatty degeneration in the liver (White and Hay 1901). No further information was provided. 

Livers from toxin-injected mice showed severe congestion whether or not the mice survived the initial critical 2-hour post injection period. Occasionally, a mouse injected with a nominally lethal dose of toxin-LR survived the critical two hours but remained listless until it died several hours or several days later. The reasons for the delayed death are unknown. Such mice developed focal fatty degeneration of the liver and active regeneration of liver cells. 

After a single exposure of rabbits to 17 ppm for 6 hours, the sensory trigeminal nucleus was severely affected. Other effects included tubular and focal necrosis in the collecting tubules of the kidney and fatty degeneration of the liver. ... 

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