National Surgical Adjuvant Breast and Bowel Project

Paik S, Bryant J, Tan-Chiu E, et al. Real-world performance of HER2 testing— National Surgical Adjuvant Breast and Bowel Project experience. I. Natl. Cancer Inst. 2002 94 852-854. 

Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin, et al. (1998) Tamoxifen for prevention of breast cancer Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst 90 1371-1388... 

The effects of tamoxifen in women with and without CHD have been analyzed in the National Surgical Adjuvant Breast and Bowel Project Breast Cancer Prevention Trial (BCPT). This randomized, placebo-controlled study included 13,388 women at increased risk for breast cancer. The conclusions of the trial are somewhat limited by the fact that it was designed to investigate the effect of tamoxifen as a chemopreventive for breast cancer, and not its effect on CVD risk. There was no indication that tamoxifen would modify the risk of CHD in women with or without heart disease (Reis et al. 2001). 

The most relevant study is the Breast Cancer Prevention Trial (BCPT, NSABP-P1) (Fisher et al. 1998). Initiated in the USA by the National Surgical Adjuvant Breast and Bowel Project, this study recruited 13,388 women considered at high risk for breast cancer based on Gail s probability algorithm (Gail et al. 1989). 

Fig. 10.7. Effect of tamoxifen administration on incidence of invasive (left panel) or nonin-vasive (rightpanel) breast cancer. Reproduced with permission from Fisher et al. and other National Surgical Adjuvant Breast and Bowel Project Investigators (1998)... 

Wolmark N, Rockette H, Wickerham DL, et al. The benefit of leucovorin modulated fluorouracil as postoperative adjuvant therapy forprimary colon cancer results from National Surgical Adjuvant Breast and Bowel Project Protocol C-03. J Clin Oncol 1993 11 1879-1887. 

Mamounas E, Wieand S, Wolmark N, et al. Comparative efficacy of adjuvant chemotherapy in patients with Dukes B versus Dukes C colon cancer results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04). J Clin Oncol 1999 17 1349-1355. 

Hyams DM, Mamounas EP, Petrelli N, et al. A clinical trial to evaluate the worth of preoperative multimodality therapy in patients with operable carcinoma of the rectum a progress report of a national surgical adjuvant Breast and Bowel Project protocol R-03. Dis Col Rectum 1997 40 131-139. 

Smith RE A review of selective estrogen receptor modulators in national surgical adjuvant breast and bowel project clinical trials. Semin Oncol 2003 30(Suppl 16) 4. 

Smith RE, Good BC. Chemoprevention of breast cancer and the trials of the National Surgical Adjuvant Breast and Bowel Project and others. Endocr Relat Cancer 2003 10 347-57. 

In the Breast Cancer Prevention Trial (P-1), initiated by the National Surgical Adjuvant Breast and Bowel Project (NSABP) in 1992, more than 13 000 eligible women were randomized to tamoxifen 20 mg/day or placebo for 5 years (26). During 69 months of follow-up tamoxifen reduced the risk of both invasive and non-invasive cancer... 

Fisher, B., Costantino, J. P., Wickerham, D. L., Redmond, C., Kovanah, M., Cronin, W. M., Vogel, V., Robidoux, A., Dimitrov, N., Atkins, J., Daly, M., Wiend, S., Tan-Chiu, E., Ford, L., and Wolmark, N. 1998. Tamoxifen for prevention of breast cancer Report of the national surgical adjuvant breast and bowel project P-1 study. J. Natl. Cancer Inst. 0 1371-1388. 

Wohnark N, Rockette H, Mamonnas E, Jones J, Wieand S, Wickerham DL, Bear HD, Atkins JN, Dimitrov NV, Glass AG, Fisher ER, Fisher B. CUnical trial to assess the relative efficacy of fluorouracil and leucovorin, fluorouracil and levamisole, and fluorouracil, leucovorin, and levamisole in patients with Dukes B and C carcinoma of the colon results from National Surgical Adjuvant Breast and Bowel Project C-04. J Clin Oncol 1999 17(ll) 3553-9. 

AC, doxorubicin, cyclophosphamide BCIRG, Breast Cancer International Research Croup CALCB, Cancer and Leukemia Croup B FAC, fluorouracil, doxorubicin, cyclophosphamide NSABP, National Surgical Adjuvant Breast and Bowel Project Pac, paclitaxel TAC, docetaxel, doxorubicin, cyclophosphamide. 

NSABP National Surgical Adjuvant Breast and Bowel Project... 

Fisher B, Dignam J, Wolmark N, et al. Tamoxifen in treatment of intraductal breast cancer National surgical adjuvant breast and bowel project B-24 randomised controlled trial. Lancet 1999 353 1993-2000. Houghton J, George WD, Cuzick J, et al. Radiotherapy and tamoxifen in women with completely excised ductal carcinoma in situ of the breast in the UK, Australia, and New Zealand Randomised controlled trial. Lancet 2003 362 95-102. 

Fisher B, Brown A, Mamounas E, et al. Effect of preoperative chemofiier-apy on local-regional disease in women wifii operable breast cancer Findings from National Surgical Adjuvant Breast and Bowel Project B-18. J Clin Oncol 1997 15 2483-2893. 

Fisher B, Dignam J, Bryant J, et al. Five versus more than five years of tamoxifen for lymph node-negative breast cancer updated findings from the National Surgical Adjuvant Breast and Bowel Project B-14 randomized trial. J Natl Cancer Inst 2001 93 684-690. 

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