Nasal polyps

Respiratory inhalant use asthma Intranasal use seasonal or perennial rhinitis, prevention of recurrence of nasal polyps after surgical removal... 

Three years after introduction of aspirin into therapy, Hirschberg in Poznan, now in Poland, described the first case of a transient, acute angioedema/urticaria, occurring shortly after ingestion of aspirin. Reports of anaphylactic reactions to aspirin soon followed. The other major type of adverse reaction, acute bronchospasm, was described in the second decade of the 20th century. In 1920, Van der Veer reported the first death due to aspirin. The association of aspirin sensitivity, asthma and nasal polyps was first recorded by Widal in 1922. This clinical entity, later named the aspirin triad was popularized in 1968 by Samter and Beers [3], who presented a... 

Genetic factors cannot explain the recent rapid rise in asthma prevalence. Asthma appears to require both genetic predisposition and environmental exposure. Many patients with occupational asthma develop the disease late in life upon exposure to specific allergens in the workplace. Environmental influences in utero or in infancy may contribute to the development of asthma. Maternal smoking during pregnancy or exposure to secondhand smoke after birth increases the risk of childhood asthma.3 Adult-onset asthma is not uncommon and may be related to atopy, nasal polyps, aspirin sensitivity, occupational exposure, or a recurrence of childhood asthma. 

Acute and chronic sinusitis can also aggravate asthma, and antibiotic therapy of sinusitis may improve asthma symptoms.3 Nasal polyps are associated with aspirin-sensitive asthma, and adult patients with nasal polyps should be counseled against using non-steroidal anti-inflammatory medications.1,3... 

Aspirin desensitization is useful in diseases where low-level antiplatelet action is needed and in the care of patients with aspirin sensitivity and intractable nasal polyps. Lysine aspirin availability in Europe allows desensitization by inhalation at... 

Investigate for underlying diseases of nonallergic origin (i.e., anatomic abnormalities, chronic sinusitis, or nasal polyps) if combination therapy does not provide sufficient relief. 

Aspirin allergy, nasal polyps, and Traumatic head injury... 

Inhalation of monomethylhydrazine was not carcinogenic in rats or dogs, but mice exposed at 2 ppm for 1 y exhibited an increased incidence of lung tumors, nasal adenomas, nasal polyps, nasal osteomas, hemangioma, and liver adenomas and carcinomas. Hamsters exposed at 2 or 5 ppm exhibited an increased incidence in nasal polyps, interstitial fibrosis of the kidney, and benign adrenal adenomas. An increase in nasal adenomas was seen in hamsters exposed at 5 ppm. 

Scholte BJ, Kansen M, Hoogeveen AT, Willemse R, Rhim JS, van der Kamp AW, Bijman J (1989) Immortalization of nasal polyp epithelial cells from cystic fibrosis patients. Exp Cell Res 182(2) 559—571. 

Kunzelmann, K., D. C. Lei, K. Eng, L. C. Escobar, T. Koslowsky, and D. C. Gruenert. 1995. Epithelial cell specific properties and genetic complementation in a delta F508 cystic fibrosis nasal polyp cell line. In Vitro Cell Dev Biol Anim 31(8) 617—24. 

Beckmann JD, Bartzatt R, Ulphani J, et al. 1995. Phenol sulfotransferase activities and localization in human nasal polyp epithelium. Biochem Biophys Res Commun 213 104-111. 

Hypersensitivity to dipyridamole, aspirin, or any of the other product components. Allergy Aspirin is contraindicated in patients with a known allergy to NSAIDs and in patients with asthma, rhinitis, and nasal polyps. Aspirin may cause severe urticaria, angioedema, or bronchospasms (asthma). 

Nasal polyps - Treatment of symptoms associated with nasal polyps may have to be continued for several weeks or more before a therapeutic result can be... 

NSAID hypersensitivity Because of potential cross-sensitivity to other NSAIDs, do not give these agents to patients in whom aspirin or other NSAIDs have induced symptoms of asthma, rhinitis, urticaria, nasal polyps, angioedema, bronchospasm. 

Anaphylactoid reactions have occurred in patients without known exposure to NSAiDs, but they typically occur in asthmatic patients who experience rhinitis with or without nasal polyps, or who exhibit severe, potentially fatal bronchospasm after taking aspirin or other NSAiDs. 

Nasal disorders Use of the nasal spray is not recommended in patients with known chronic nasal disorders (eg, allergy, rhinitis, nasal polyps, sinusitis) because such use has not been adequately studied. 

NSAIDs can impair renal function, cause fluid retention, and provoke hypersensitivity reactions, including bronchospasm, aggravation of asthma, urticaria, nasal polyps, and rarely, anaphylactoid reactions. These reactions may occur even in those who have previously used NSAIDs without any ill effects. NSAIDs inhibit uterine contraction and can cause premature closure of the fetal ductus arteriosus. 

Long-term control of Bronchial asthma, reduces need for oral corticosteriod therapy for asthma Oral Inhalation 40-160 meg twice a day. Maximum 320 meg twice a day. Rhinitis, prevention of recurrence of nasal polyps Nasal Inhalation 1 spray in each nostril 2-4 times a day or 2 sprays twice a day. Maintenance 1 spray 3 times a day. 

Unlabeled Uses To prevenl recurrence of nasal polyps after surgery... 

Contraindications Aspirin-induced nasal polyps associated with bronchospasm... 

Shin disease Topical Apply cream, lotion, or ointment to affected area once a day Nasal polyp Nasal spray 2 sprays in each nostril twice a day... 

Syzygium aromaticum (L.) Merr. Perry Ding Xian (Clove) (clove bud) Phytosterols, campesterol, crataegol acid, sitosterols, stigmasterol, niacin, ascorbic acid.50 Antiemetic, carminative, stimulant, treat diarrhea, halitosis, nasal polyps, uterine fluxes, sterility, toothache. 

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