N-Methyl pyrrole

Reaction of N-acetyl-lO-bromodibenzazepine 51 with potassium ferf-butoxide yields the reactive intermediate 52 that reacts with N-methyl pyrrole 53 (X = NMe) used as a solvent to produce a mixture of Diels-Alder/retro Diels-Alder adduct 54 with the Michael by-product 55 (X = NMe, Scheme 10 (1994JHC293)). 

Similarly, methylation of pyrrolo-benzothiazepines 172 (Scheme 34, Section 2.3.1 (1994MI283)) and 307 (Scheme 66, Section 3.3.1.2 (2005FES385)) with methyl iodide in acetone in the presence of potassium carbonate proceeds regioselectively and produces N-methyl pyrrole derivatives as sole products. Methylation on the thiazepine ring nitrogen requires stronger base, i.e. potassium ferf-butoxide, to give dimethyl 174 and 311, respectively. 

Singh et al. have used perhydrol,3-heterocycle 253 as carbonyl equivalent for acid (TFA)-catalyzed dipyrro me thane 254 synthesis (Scheme 99) using only stoichiometric amounts of pyrrole/N-methyl pyrrole and products were obtained in good yield with formation of tripyrromethanes 255 (05T6614,05SC929). 

During the last decade, immobilization of oxidase type enzymes by physical entrapment in conducting or ionic polymers has gained in interest, particularly in the biosensor field. This was related to the possibility for direct electron tranfer between the redox enzyme and the electroconducting polymers such as polypyrrole (1,2), poly-N-methyl pyrrole (3), polyindole (4) and polyaniline (5) or by the possibility to incorporate by ion-exchange in polymer such as Nafion (6) soluble redox mediators that can act as electron shuttle between the enzyme and the electrode. 

Pyridine o-Xylene Hexa- fluorobenzene Quinoline Relative amounts4 Thiophene N-Methyl- pyrrole Benzonitrile... 

N-methyl pyrrole 2.34, thiophene, and furan can be metallated at the C2 position with alkyl lithium reagents. This position is more activated to deprotonation than the C3 position because of the electron-withdrawing inductive effect of the heteroatom. The nucleophilic 2-lithio species can then be reacted with various electrophiles, as in the preparation of 2.37, 2.38,... 

Heterocyclic compounds containing a nitrogen atom commonly undergo N-alkylation or C-alkylation. N-Methyl pyrrole can be prepared by interaction of methyl iodide with potassium pyrrole (40%). N-Carbethoxy pyrrole is made from chloroformic ester and potassium pyrrole. The C-alkylation of pyrroles has been discussed. 3-Alkylindoles are made by the alkylation and decarboxylation of indole-2-carboxylic acid. The conditions for alkylation of pyrrolidine are analogous to those employed for the alkylation of a secondary amine. Thus, pyrrolidine on treatment with n-butyl bromide and potassium hydroxide in boiling benzene is con-... 

A single crystal X-ray diffraction analysis of this abovementioned N(21)-methyl copper(II) corrole 2.215 confirmed the site of methylation to be at N(21). This same structure also revealed a rather distorted molecule with the N-methylated pyrrole ring being twisted out of the mean plane of the remaining pyrrolic portions of the macrocycle. Thus, this X-ray structure was seminal in its time. It provided both a... 

C4H10O methyl propyl ether 557-17-5 133.97 7.670 1 4658 C5H7N N-methyl pyrrole 96-54-8 216.91 7.820 1... 

It should be noted that the CHj group and the nitrogen-bound carbon atom of the carbazole moiety ue subject to the same effect, arising from the dipolar coupling to the quadrupolar N nucleus. In this case, however, since the quadrupole coupling constant is much smaller than for the bromine isotopes (2.16 MHz for N-methyl pyrrole (29)) the interaction is much weaker and manifests itself only as a moderate broadening of the peaks with some ill-resolved structure. For these asymmetric resonances, the chemical shifts were measured at the center of gravity. 

Immobilization matrix poly-N-methyl pyrrole glucose [9]... 

N-substituted pyrroles as potential end-capping reagents in the quasiliving carbocationic polymerization of PIBs. The TiCl4-co-initiated polymerization of PIB was quenched with N-methylpyrrole to form a mixture of 2- and 3-PIB-N-methyl-pyrrole-fimctionalized polymer in quantitative yield as determined by Catalytic hydrogenation of the... 

For the first time the phenomenon of significant rise of not only initial rate (W j), but also the selectivity (S = [PEH] / A[RH] 100%) and conversion degree (C = A[RH]/[RH]p 100%) of oxidation of alkylarens (ethylbenzene, cumene,) into ROOH by molecular O2 under catalysis by transition metals complexes M(L )2 (M = Ni(ll), Co(ll), L =acac ) in the presence of additives of electron-donor monodentate ligands (L = HMPA (hexameth-ylphosphorus triamide), dimethyl fomiamide (DMF), N-methyl pyrrol-idone-2 (MP)), MSt (M = Li, Na, K) was found by authors of the articles [55-57]. 

Enolates derived from acyclic and cyclic aliphatic ketones can easily be arylated by the SrnI process. These reactions are usually conducted in dimethylsulfoxide (DMSO) or liquid ammonia as solvent. As an example, the photoinduced arylation of the enolate derived from 2-acetyl-N-methyl pyrrole with iodobenzene in... 

Zhou, Q.-X., Miller, L. L., and Valentine, J. R., Electrochemically controlled binding and release of protonated dimethyldopamine and other cations from poly(N-methyl pyrrole)/polyanion composite redox polymers, J. Electroanal. Chem., 261, 147-164 (1989). 

Physical properties 1-Formyl-piperidine N-Methyl- pyrrol- idone 2-Pyrrol- idone Form- amide N,N-Di- methyl- form- amide N,N-Di- methyl- acet- amide Aceto- nitrile Morpho- line N-Methyl morpho- line... 

Megasolv NOC/ Petroferm Propoxy propsuiol, methoxy and method ethyloxy propanol, and N-methyl pyrrol idone Room temperature cleaning of electronic assemblies, surface-mount adhesive cleaning (misprints and stencils). Used in pressure spray, immersion, and ultrasonic applications. N/A 180-202 Low N/A 82 <1 (20°C)... 

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