Poly-N-Methyl-Pyrroles and Imidazoles

New polyamides based on homo- and/or hetero-pyrrole and imidazole amino acids have been designed for high-affinity recognition of the minor groove of DNA (Fig. 7.12). 

The rapid solid-phase synthesis of pyrrole-imidazole polyamides with a wide variety of sequences and the generation of combinatorial libraries should increase the possibilities for the recognition of any desired DNA double strand. 

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