N-methyl propanamide

Fig. 7.20 Illustration of the additivity of conformational geometry functions for the 41-rotation in (CH3NH)(0=)C-C(CH3)(H)(NHCOCH3) (ALA). During the torsional motion about the C(a)-C bond of ALA, the interactions within the system are the same as those encountered during the C(=0)-C torsion in N-methyl propanamide (NMPA), plus those encountered during the C(ct)-C torsion in N-acetyl N -methyl glycine amide offset by 120° as shown (GLY), minus those encountered during the C-C torsion in N-methyl acetamide (NMA).

For the i (-rotation in ALA (Fig. 7.20), the corresponding combination involves N-methyl propanamide, NMPA, plus GLY, minus NMA. For more details concerning the addition of CGF see (Schafer et al. in press, G). 

Dispersion energy maps of benzene and N-methyl propanamide with neon as a probe. The SAPT(DFT) dispersion energy is displayed using an absolute scale inkJ mol". The model... 

Diethyl ether, methyl n-propyl ether, diethylamine, N-methyl-1 -propanamine, acetone, allyl alcohol, dimethylformamide, propanamide, 2-methylpropan-amide, 2,2-dimethylpropanamide, benzamide, dichloromethane, toluene, ethyl N-acetyl-glycinate, -alaninate, -methioninate, and -aspartate, ethyl acetate, tetrahydrofuran... 

Smiles rearrangement. The Smiles rearrangement is ordinarily limited to substrates in which the aromatic ring is activated by an electron-withdrawing substituent. However, if HMPT is used as solvent, 2-aryloxy-2-methylpcopana-mides (1) arc rearranged by sodium hydride to N-aryl-2-hydroxy-2-methyl-propanamides (2) in 50-85%, yield. The products are hydrolyzed by acid to anilines (3). ... 

NaH-dispersion added carefully to a soln. of 2-(benzo[b]thien-4-yloxy)-2-methyl-propanamide in dry hexamethylphosphoramide, and heated 1 hr. on a steam bath N-benzo[b]thien-4-yl-2-hydroxy-2-methylpropanamide. Y 72%. - This is a stage of a 4-step sequence for the prepn. of ar. amines from phenols. F. e. s. R. Bayles et al., Synthesis 1977, 33, 31. 

Obtained by reaction of N-methoxy-N-methyl-C0C(CH3)3 2,2-dimethyl-propanamide with 2-methoxynaph-thalene (multistage) [8354]. 

Chemical Name 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl] -propanamide Common Name Niftolid... 

Talley, J. J., Bertenshaw, S. R., Brown, D. L., Carter, J. S., Graneto, M. J., Kellogg, M. S., Koboldt, C. M., Yuan. J., Zhang, Y. Y., Seibert, K. N-[[(5-methyl-3-phenylisoxazol-4-yl)-phenyl]sulfonyl]propanamide, sodium salt, parecoxib sodium A potent and selective inhibitor of COX-2 for parenteral administration, J. Med. Chem. 2000b, 43, 1661-1663. 

Chemical Name Propanamide, N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methyl- (racemic mixture)... 

Chemical Name (S)-2-Methyl-N-[3-(2,3,5,6-tetrahydroimidazo[2,l-b]thiazol-6-yl)phenyl]propanamide monohydrochloride... 

To increase the marketability of Collego, its compatibility with chemical pesticides has been investigated. Mixtures of CGA with propanil [N-(3,4-dichlorophenyl)propanamide], molinate [S-ethyl hexahydro-lH-azepine-l-carbothioate], 2,4,5-T, and benomyl [methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate] were detrimental to CGA s efficacy (31). If, however, propanil, 2,4,5-T, fentin hydroxide (triphenyltin hydroxide), pencycuron N-[(4-chlorophenyl)methyl]-N-cyclopentyl-N -phenylurea), each at 0.56 kg ai/ha, and SN-84364 [3 -isopropoxy-2-(trifluoromethyl) benzanilide] (at 0.40 kg ai/ha) were applied after CGA treatment, disease and development were not inhibited (32). The herbicides, acifluorfen 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid) (0.56 kg ai/ha) and bentazon [3-(1-methylethyl)-(IH)-2,1,3-benzothiadiazin-4(3H)-one 2,2-dioxide] (0.56 to 1.1 kg ai/ha), or the insecticides, malathion [diethyl(dimethoxyphosphinothioylthio)succinate] (0.56 kg ai/ha) and carbofuran (2,3-dihydro-2,2-dimethyl-7-benzofuranyl methylcarbamate), (0.56 kg ai/ha) could be applied with CGA from a single tank mixture (33-34). ... 

The re-entrant phase diagram experimentally observed for proteins has also been observed for a number of water-soluble polymers. As expected, the sidechains of the polymers are able to form hydrogen bond interactions with water. Poly(ethylene oxide) [92] and poly(vinyl methyl ether) [93] form weak hydrogen bonds via their ether groups. Poly(N-vinylpyrrolidone), poly(N-isopropylacrylamide) [94], poly(N-vinylisobutyramide) [94], poly(N-vinylcaprolactam) and poly(2-acrylamido-2-methyl-l-propanamide) [95] contain amide groups in their side chains. It is well known that hydrogen bonds to ethers are much weaker than those formed with amides. It is clear that these polymers also show hydrophobic interactions. 

An accelerated diastereoselective variant of the amide acetal Claisen rearrangement is the reaction between the lithium alkoxide of ( )- or (Z)-2-butenol with salts derived from alkylation of propanamides or fluoroacetamides with methyl triflate or dimethyl sulfate. This reaction yields directly the [3,3] sigmatropic rearrangement products of the corresponding N.O-ketene acetals at room temperature, e.g., formation of 7/8 and 12/13 (Table 8)4fiI-462. 

The X-ray crystal structure has been determined for 2-isopropylamino-5-phenyl-6-methyl-67/-l,3,4-thiadiazine 24 <1993ACS302>. The structure of this compound may be described as a skew boat form. The bond lengths C(2)-NHPr and C(2)-N(3) indicate that the amine tautomer is preferred in the solid state. Analogous results are observed for A -[5-aryl-6/7-l,3,4-thiadiazin-2-yl]2-[(phenylsulfonyl)amino]propanamides 25 <2001AXC593>. The X-ray crystal structure of the l,3,4-thiadiazino[6,5,4-r,/ ]quinoline derivative 26 has been reported <1998MC131>. 

Each hydrogen of a primary amide typically has a separate H-NMR resonance, as illustrated by the separate signals for the two amide hydrogens of propanamide, which fall at 8 6.22 and S 6.58. Furthermore, each methyl group of N,N-dimethylformamide has a separate resonance 8 3.88 and 8 3.98). How do you account for these observations ... 

Parecoxib, N- [4-(5-methyl-3-phenylisoxazol-4-yl) phenyl] sulfonyl propanamide, is an inactive prodrug of valdecoxib. After injection, either intramuscular or intravenous, parecoxib rapidly imdergoes hepatic... 

Synonyms N-Phenyl-N(l-(0-methyl-2-phenylethyl)-4-piperidinyl]-propanamide Trade names ... 

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