N -Methyl-A-

A mixture of 39.0 grams (0.2 mol) of a-methylhomoveratrylamine and 42.0 grams (0.2 mol) of 3-methoxy-4-ethoxyphenylacetic acid is heated at 190°-200°C for one hour. The reaction mixture is poured into about 100 cc of petroleum ether, whereupon crystals of N-(a-methyl-homoveratryl)-3-methoxy-4-ethoxyphenylacetamide separate. The precipitate is filtered off, and recrystallized from 50% methanol-water. 

A number of substituted benzenesulfonic acid esters and p-chlorophenoxy-isobutyric acid esters produced hypolipidemic activity.35 Among a series of p-alkoxybenzoic acids, enhanced hypotriglyceridemic and hypocholesterol-emic activity was observed with oximino- (14) and chloro- (15) substituents.98 Hypocholesterolemia was observed after the administration of 16 to rats.97 Tetronic 701, a polymeric surfactant, also lowered serum cholesterol the tetrabenzoate of Tetronic 701 is of particular interest, since it produced comparatively less growth depression.98 Two linoleamide derivatives, (-)N-fa-phenyl-B-(p-tolyl)ethylllinoleamide (PTLA) and N-(a-methyl-benzoyl)linoleamide, suppressed serum and liver cholesterol levels in rats and inhibited cholesterol absorption b interfering with the hydrolysis of cholesteryl esters in the intestine.99 101... 

The mass spectral peaks mje 124 (y) and 109 (w), together with the N(a)-methyl and methoxycarbonyl groups, indicate that the second component is pleiocar-... 

L = bis(hydroxymethyldihydroxyoxazolyl)pyridine = 1,4-bis(diphenylphosphanyl)butane L = (S,S)-2,6-bis-(4-isopropyl-2-oxazolin-2yl)pyridine PS-PEG = polystyrene-poly(ethyleneglycol) L-abrine = N-(a)-methyl-L-... 

NCvH Benzene, 2-isocyano-l,3-dimethyl-, iron complexes, 26 53-57 NC,H,3, Benzenemethanamine, N,N-Ai-methyl-, lithium complex, 26 152 palladium complex, 26 212 NCiH 3, Benzenemethanamine, N,N-A -methyl-, lutetium complex, 27 153... 

PROBLEM-SOLVING / f product This product results fr n a methyl shift (represented by the symbol CH3), the... 

In 2012 we also use this class of catalysts to reduce a series of iV-benzyl and N-a methyl benzyl (3-enaminoesters (Scheme 15.12) [39]. Best results were obtained with Cat. 8 and, once again, an improvement of the enantioselectivity was observed by using chiral auxiliary. Then, hydrogenolysis of the enantiomerically enriched N-benzyl (3-aminoesters, followed by LDA-promoted ring closure, afforded enantiomerically pure 4-aryl or 4-aIkyl substituted p-lactams. 

N -a-Methyl-N-Dca-Asp Di-Bzl-ammonium salt -OPic-Z-Asp-OTcp a-T ritio-Di Asp 5-Aminovaleric acid Z-J-Ave Citruflene Boc-Cit Dcha Boc-Cit-OPcp Cysteine... 

Macro-Prep methyl divinylbenzene Methacrylate 50 1-14 n.a. Methyl >25 HSA molecular-weight molecules Bio-Rad... 

However, in forming the second product, something more fundamental has clearly occurred— a hydrogen atom has migrated (notice that this is n a methyl migration, which would only lead to exactly the same secondary carbocation). Specifically, this has happened to the initially produced carbocation, so that the secondary carbocation is converted into the tertiary one, prior to capture by the chloride ion. This is an example when it s helpful to think about the reaction backward from the end—what carbocation was captured by the chloride to give the second product That s the one we need to get to, so we do the migration that is required to achieve it. 

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