A N-methylated

Figure 5.1. Variation of half-wave potential (E ) with pH for a-subslituted ketones (a) N-methyl-N-phenacylpiperidinium cation, (b) N-methyl-N-(2-oxopropy )piperidimum cation, (c)diethyl-(phenacyl)-sulphonium cation. Data from refs. (90] and [91].

Allen, R. M. and Dykstra, L. A. N-Methyl-D-aspartate receptor antagonists potentiate the antinociceptive effects of morphine in squirrel monkeys, J. Pharmacol. Exp. Ther. 2001, 298, 288-297. 

Nikolajsen, L., Gottrup, H., Kristensen, A. G. D., Jensen, T. S. Memantine (a N-methyl-D-aspartate receptor antagonist) in the treatment of neuropathic pain after amputation or surgery a randomized, double-blinded, cross-over study, Anesth. Analg. 2000, 97, 960-966. 

CGP68730A a N-methyl-D-aspartate antagonist acting at the strychnine-insensitive glycine site, Prog. Neuropsychopharmacol. Biol. Psychiatry 2000, 24, 547-670. 

Sotgiu, M. L. and Biella, G. Differential effects ofMK-801, a N-methyl-D-aspartate non-competitive... 

Signal transduction was studied most precisely for the 5-HTiA receptor in rat amygdala (Koyama et al. 1999). The receptor operated through a N-methyl maleimide-sensitive mechanism and by adenyl cyclase inhibition rather than any change in K+ or Ca2+ channels. The fall in cyclic AMP presumably was followed by decrease in the phosphorylation of synaptic vesicle proteins and, finally, in a decrease of exocytosis. 

The Schiff base a-N-methyl-S-methyl-P-iV-(2-hydroxyphenyl)methylenedithiocar-bazate (144) loses a proton on co-ordination to nickel(n) to function as a terdentate NOS donor in [Ni(L - H)X](X = Cl, Br, or NCS), all planar diamagnetic complexes. Similarly the Ni(L — H)2 complex is octahedral //eff = 3.10 BM.601... 

Protecting the amino group at N-6 in the form of A -(N-methyl-2-pyrroli-dineylidene)adenine improves the N-9 selectivity, although the yield tends to be lower. [For an account of the work by Jahne and co-workers see (93MI2).]... 

P. B. Hitchcock, M. F. Lappert, G. M. McLaughlin, and A. J. Oliver, Complexes of Imidoyl Chloride and Rhodium(I) Precursors, and the Crystal and Molecular Structure of Carbonyltri-iodo-[a-(N-methyl-a-methyliminobenzylamino)benzylidene-N,C]rho-dium, J. Chem. Soc., Dalton Trans. 1974, 68-74. 

In some cases, a group cross-links across a ring and hence creates two further rings however, clarity dictates that in this case the cross-link is indicated simply in square brackets. Thus, a compound with a ring cross-linked with a N-methyl group would be denoted X[-CH3-N<], the epoxy analogue as X[—O—] (or X[epoxy]) and the dimethylene cross-link analogue as X[—CH2—CH2—]. 

Figure 14.6 Typical cations and anion of an ionic liquid with an ammonium cation, (a) N-Methyl-N-propyipiperidinium cation (PP13) (b) trimethylpropylammonium cation (TMPA) (c) bisftrifluoromethane suifonyl)imide anion (TFSI).

A representative sphingophosphonolipid in which the aminoethylphosphonate head group may contain a hydroxy group (R = OH) or a N-methyl group (R" = CH3)... 

Duan M, Agerman K, Ernfors P, Canlon B. Complementary roles of neurotrophin 3 and a N-methyl-D-aspartate antagonist in the protection of noise and aminoglycoside-induced ototoxicity. Proc Natl Acad Sci USA 2000 97(13) 7597-602. 

The transporter does also accept some dipeptides with a N-methylated peptide bond exemplified by Gly-Sar and some tripeptides with N-methylated amide bond however, N-methylation does not seem to be a general stabilization approach, since the affinity for PEPT1 is not retained for all the investigated compounds [113, 114],... 

The rate-controlling step of catecholamine synthesis is the tyrosine hydroxylase reaction, for which the catecholamines are allosteric inhibitors. The enzyme is activated by the cAMP-dependent protein kinase phos-phorylating system. a-N-Methyl-p-tyrosine is an inhibitor of this enzyme and is used to block adrenergic activity in pheochromocytoma (see below). 

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