Myeloid cancers/myeloma

Cancers Multiple myeloma Non-Hodgkin s lymphoma Hodgkin s disease Acute myeloid leukemia Neuroblastoma Germ cell tumors Acute myeloid leukemia Acute lymphoblastic leukemia Chronic myeloid leukemia Myelodysplastic syndrome Myeloproliferative disorders Non-Hodgkin s lymphoma Hodgkin s disease Chronic lymphocytic leukemia Multiple myeloma... 

Over 70% of transplantations were carried out concerning lympho-granulematosis, lymphoma, and myeloma others are connected with testicular cancer, acute myeloid leukemia, solid tumors and other oncological diseases. The lethality related with transplantation (100-days lethality among the transplanted patients) was 2,3% (died 4 patients) within 5 years. At the beginning of 2006 56% of all transplanted patients did not have the signs of basic disease progression. 

A number of inhibitors of various tyrosine kinase enzymes are important new cancer drugs sunitinib (Sutent) is used for the treatment of certain kidney and GI cancers imatinib (Glivec) for chronic myeloid leukemia and GI tumours, and lapatinib (Tykerb/Tykerv) for breast and lung cancers. Bortezomib (Velcade), a proteasome inhibitor is used to treat multiple myeloma and is notable for being a boronic acid. 

In a re-evaluation of the Hanford cohort, which included approximately 28,000 male and female workers, Kneale et al. (1981) detected a significant increase in the cancers in radiosensitive tissues in workers exposed to external radiation. Radiosensitive tissues grouped together in their analyses included cancers of the stomach, large intestine, pancreas, pharynx, lung, breast, reticuloendothelial system (lymphoma, myeloma, myeloid leukemia and others), and thyroid. Approximately 50% of these cancers were in the lung however, smoking histories were not considered in the analysis. Of the male population, only 3% or 225 men had definite evidence of internal radiation. Due to this fact the authors stated that they could safely assume that the incidence of cancer from internal radiation was small compared with that associated with external radiation. 

On some human cancers, e.g., natural killer-like and T-cell malignant lymphomas, acute myeloid leukemia, multiple myeloma, and some head and neck tumors, polySia expression may enhance neuroinvasive potential and metastases... 

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