Basic Diseases

Some allergic or allergy-like reactions are markedly influenced by basic diseases  

The increase of maculopapular exanthemas by aminopenicillins in infectious mononucleosis and in lymphatic leukosis 

Erythema nodosum, encountered in 5% of children with tuberculosis. This rate increased to 45% if a sulphonamide preparation (sulphathiazole) was administered (Rollof 1950). 

In both examples, the pathogenesis is not clear and an allergic origin has not been proved. 

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Singularity of the Drug. The principle involved in the singularity method of linking a drug with an ADR is based on two assumptions Only one drug was administered, and there was no basic disease or co-morbid state that could be related to the ADR marker being used in the assessment. 

Over 70% of transplantations were carried out concerning lympho-granulematosis, lymphoma, and myeloma others are connected with testicular cancer, acute myeloid leukemia, solid tumors and other oncological diseases. The lethality related with transplantation (100-days lethality among the transplanted patients) was 2,3% (died 4 patients) within 5 years. At the beginning of 2006 56% of all transplanted patients did not have the signs of basic disease progression. 

Post, T. M., Freijer, J. I., Dejongh, J., Dan-hof, M. Disease system analysis basic disease progression models in degenerative disease. Pharm Res 2005, 22 1038-1049. 

AA amyloid appears in a generalized form and is mainly stored perireticularly in the kidney, spleen and liver. This kind of amyloidosis occurs as (1.) a congenital form in cases of familial Mediterranean fever, (2.) an idiopathic (= primary) form without any associated basic disease, and (i.) a reactive (= secondary) form in chronic inflammations or tumours (e.g. Hodgkin s disease) as well as in drug abuse and AIDS. 

Raanani P, Segal E, Levi I, Bercowicz M, Berkenstat H, Avigdor A, Perel A, Ben-Bassat I. Diffuse alveolar hemorrhage in acute promyelocytic leukemia patients treated with ATRA—a manifestation of the basic disease or the treatment. Leuk Lymphoma 2000 37(5-6) 605-10. 

A. I have been asked, at one time or another, if the use of intravenous hydrogen peroxide and ultraviolet light (photox) will help almost every disease known to mankind. My answer, in most cases, is "I don t know." Unfortunately, I must give the same answer in this case. I would say that photox is probably ineffective for the basic disease of the pancreas. However, most patients with chronic diseases are subject to infections which photox will help, so the treatment might be useful for a better quality of life. 

This example is a basic disease progression model with an component used to describe only the change in disease severity over time. Consequently, the model can be handled using pred rather than the pk. 

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