Muscle pain vitamin

Vitamin D Decreased appetite, decrease of calcium levels in bones, increase of calcium levels in blood, muscle pain and weakness, constipation, vomiting, kidney stone... 

In a 6-week study to evaluate the effectiveness of Vitamin D supplementation (vitamin D2 or D3 2000lU, or vitamin D2 50,000 lU weekly) compared with calcium for treatment of vitamin D sufficiency in children with inflammatory bowel disease was examined [49 ]. The most commonly reported events were nausea (n=6) increased thirst and loss of appetite (n=5 each) pruritus (n=4) drowsiness and increased urinary frequency (n=3 each) abdomirwl pain, hone pain, headache and constipation (n=2 each) rash, sensitive eyes, vomiting, irregular heartbeat, dry mouth and muscle pain (n=1 each). There were no significant differences in the frequency of adverse events between groups, and no serious adverse events were observed. 

Primary hyperparathyroidism occurs as a result of hyperplasia or the occurrence of adenoma. Secondary hyperparathyroidism may result from renal failure because of the associated phosphate retention, resistance to the metabolic actions of PTH, or impaired vitamin D metabolism. The last-mentioned factor is primarily responsible for the development of osteomalacia. Muscle symptoms are much more common in patients with osteomalacia than in primary hyperparathyroidism. Muscle biopsy has revealed disseminated atrophy, sometimes confined to type 2 fibers, but in other cases involving both fiber types. Clinical features of osteomalacic myopathy are proximal limb weakness and associated bone pain the condition responds well to treatment with vitamin D. 

The nutritional experiments with carotene and fish oils led to the conclusion that a second fat-soluble compound was essential for normal rat growth. Rickets, the condition caused by vitamin D deficiency, is a disease afflicting children where, because of impaired calcification, bone formation is disturbed and the bones become bowed and otherwise deformed. In adults, especially multiparous women, vitamin D deficiency produced osteomalacia—demineralization of bone, leading to tenderness over the bones, pain, and muscle weakness. Rickets was particularly prevalent in slum areas. Glasgow, Vienna, and Lahore were notorious for the high incidence of the disease. 

Vitamin D deficiency after epiphyseal fusion causes osteomalacia, which produces less deformity than rickets. Osteomalacia may present as bone pain and muscle weakness. 

The choice of vitamin D preparation to be used in the setting of chronic renal failure in the dialysis patient depends on the type and extent of bone disease and hyperparathyroidism. No consensus has been reached regarding the advisability of using any vitamin D metabolite in the predialysis patient. l,25(OH)2D3 (calcitriol) will rapidly correct hypocalcemia and at least partially reverse the secondary hyperparathyroidism and osteitis fibrosa. Many patients with muscle weakness and bone pain gain an improved sense of well-being. 

Osteomalacia is the defective remineralization of bone during normal bone turnover in adults, so that there is a progressive demineralization, but with adequate bone matrix, leading to bone pain and skeletal deformities, with muscle weakness. Women with inadequate vitamin D status are especially at risk of osteomalacia after repeated pregnancies, as a result of the considerable drain on calcium reserves for fetal bone mineralization and lactation. 

Intoxication with vitamin D causes weakness, nausea, loss of appetite, headache, abdominal pains, cramps, and diarrhea. More seriously, it also causes hypercalcemia, with plasma concentrations of calcium between 2.75 to 4.5 mmol per L, compared with the normal range of 2.2 to 2.5 mmol per L. At plasma concentrations of calcium above 3.75 mmol per L, vascular smooth muscle may contract abnormally, leading to hypertension and hypertensive encephalopathy. Hypercalciuria may also result in the precipitation of calcium phosphate in the renal tubules and hence the development of urinary calculi. Hypercalcemia can also result in calcinosis - the calcification of soft tissues, including kidneys, heart, lungs, and blood vessels. This is assumed to be the result of increased calcium uptake into tissues in response to excessive plasma concentrations of the vitamin and its metabolites. 

Cholestasis-linked osteopathy (M. Loeper et al., 1939), which occurs much more frequently in the form of osteoporosis than osteomalacia, can be expected in up to 50% of cases. The pathogenesis is complex. Vitamin D status can be examined by determining 25-OH-cholecal-ciferol in the serum. Intestinal calcium loss and reduced calcium absorption due to vitamin D deficiency are key pathogenetic factors. It is still a matter of debate whether vitamin K deficiency (which can lead to reduced osteocalcin synthesis) and deficiencies in IGF I and II (which can cause dysfunction of the osteoblasts) are possible causes of this condition. Muscle and bone pain are frequent clinical symptoms, occurring mainly in the wrists and ankles. 

After the plasma Mg levels had decreased, plasma calcium levels began to drop. The drop in plasma Ca was moderate compared with that in Mg, Plasma Ca levels decreased even though the subjects were receiving adequate amounts of calcium and vitamin D. Neuromuscular symptoms developed after about 4 weeks of the diet. These symphims included tetany, lack of reflexes, tremors, and muscle lAreak-ness. Tetany may be mild, as in mouth twitches, or more severe, as in painful spasms. Hypocalcemia produces a tetany similar to that produced by Mg defi cicncy however. Mg deficiency induced tetany can occur with normal serum calcium levels. The tetany of Mg deficiency can be reversed by administration of Mg but not calcium. Tetany can result from low concentrations of Ca or Mg in the extracellular fluids which surround the nerves) or from an alkaline pH. Low potassium levels in the extracellular fluids, however, do not result in tetany. 

Isolated nutritional deficiencies. Iron, folate, or vitamin Bi2 deficiency may manifest as anemia, which may be mild vitamin K deficiency as a bleeding tendency and vitamin D deficiency as bone disease. They are reflected by a variety of signs and symptoms (glossitis, pallor, dermatitis, petechiae, bruising, hematuria, muscle or bone pain, or neurological abnormalities). 

Osteomalacia, although less common than osteoporosis, can be insidious and coexist with osteoporosis. A serum 25-hydroxyvitamin D concentration should be obtained in anyone with decreased oral vitamin D intake, limited or no sun exposure, or unexplained muscle weakness or pain. 

In adults, vitamin D deficiency results in osteomalacia, a disease characterized by generahzed accumulation of undermineralized bone matrix. Severe osteomalacia may be associated with extreme bone pain and tenderness and proximal muscle weakness. A low serum level of 25-OHD is diagnostic. 

Vitamin C RDA F 75 mg M 90 mg UL 2g Citrus fruits potatoes peppers, broccoli, spinach strawberries Scurvy defective collagen formation leading to subcutaneous hemorrhage, aching bones, joints, and muscle in adults, rigid position and pain in infants. 

Ingestion of excessive quantities of vitamin D may be toxic, and can result in bone and/or pain, diffuse demineralization of bones, muscle fatigue, loss of appetite, thirst, sore eyes, itchy skin, vomiting, diarrhea, urinary urgency, and abnormal calcium levels in the urine (indicative of kidney stones). High doses of vitamin D cause a build-up of calcium in soft tissues and in organs such as the liver, lungs, heart, kidneys, and muscles (Watson et al., 1997). 

Beriberi is a neurological and cardiovascular disorder that is caused by a deficiency of thiamine (also called vitamin Bj). It has been a serious health problem in Asia and continues to be in those places where rice is the main staple food. The problem is exacerbated if the rice is dehusked (polished) because only the outer layers of the seeds contain appreciable amounts of thiamine. Beriberi also occurs in some malnourished chronic alcoholics, so to avoid this problem in some countries certain alcohol-containing drinks are fortified with thiamine. Beriberi is characterized by pain in the limbs, weak muscles, abnormal skin sensation, and an enlarged heart with inadequate cardiac output. Which biochemical processes are affected by thiamine deficiency ... 

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