Mucous hypersecretion

Airway Secretion Physiological Bases for the Control of Mucous Hypersecretion, edited by T. Takishima and S. Shimura... 

Talniflumate is an inhibitor of calcium-activated chloride channels, which has been developed to treat mucous hypersecretion (1). It is a phthalidyl ester of pyridine-carboxyUc acid, related to niflumic acid. 

The two most prevalent chronic inflammatory lung diseases are asthma and chronic obstructive pulmonary disease (COPD). These diseases are a major and increasing global health problem. Both asthma and COPD share some clinical features, such as increased airway obstruction, mucous hypersecretion, acute exacerbations and respiratory symptoms. Asthma and COPD are identified by the presence of chronic inflammation of the airways, which is controlled by the increased expression of inflammatory proteins, including cytokines, chemokines, receptors, enzymes and... 

Mucous hypersecretion present, but airway inflammation is confined to large airways Can lead to death in nonchnical species (pulmonary edema/hemorrhage, pleural effusion)... 

Pneumocystis carinii Pneumonia Second Edition, eckted byP.D. Walzer 70. Fluid and Solute Transport in the Airspaces of the Lungs, edited by RM.Effros and H.K.Chang 71. Sleep and Breathing Second Edition, edited by N.A.Saunders andC.E.Sullivan 72. Airway Secretion Physiological Bases for the Control of Mucous Hypersecretion, edited by T.Takishima andS.Shimura... 

A large amount of sputum is a characteristic manifestation of DPB. Sputum volume markedly decreases after EM therapy. The reduction of sputum volume is the most sensitive parameter as shown by the double-blind study mentioned here. Goswami et al. [11] first reported that EM dose-dependently inhibited mucous secretion from airway mucosa with a marker of glycoconjugate in vitro. Tamaoki et al. [12] first observed in vitro ion transport on epithelial cells and reported that EM dose-dependently inhibited ion transport when erythromycin attached to the serosa. Furthermore, they found this inhibition was due to blocking of the chloride channel. The inhibition of the chloride channel also means that erythromycin inhibits the secretion of water that moves with the chloride ion. Inhibition of mucus and water secretion from the epithelial cells can be interpreted as an important mechanism of action in improving hypersecretion in patients with DPB. 

Illustrated in Figure 3 is a likely over-all mechanistic role of theophylline in asthma. Extrinsic or immediate hypersensitivity-type asthma begins with an antigen -antibody complex at mast cells and results in the release of chemical mediators which affect cells in airways. Smooth muscle cells contract, capillaries leak, and secretory cells hypersecrete to give a triad of bronchospasm, edema and Increased mucous, respectively. Shown is the two-enzyme... 

Drying effect on mucous membranes, reduces hypersecretions... 

Mucus hypersecretion Mucous gland enlargement Smooth muscle hyperplasia Bronchial wall thickening Inflammation Emphysema... 

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