Mucositis chemotherapy-induced

Zhang Q, Nguyen AL, Shi S et al (2011) Three-dimensional spheroid culture of human gingiva-derived mesenchymal stem cells enhances mitigation of chemotherapy-induced oral mucositis. Stem Cells Dev 21(6) 937-947... 

First- and second-trimester abortion Cervical reopening Induction of labor Augmentation of labor Postpartum hemorrhage Ectopic pregnancy Lactation suppression In gastrointestinal disease Peptic ulceration Liver transplantation Chemotherapy-induced mucosal lesions In cardiovascular disease Congenital cardiac malformations Raynaud s syndrome Chronic obstructive pulmonary disease Adult respiratory distress syndrome Pulmonary hypertension Arterial occlusive disease Extracorporeal circulation In urology Erectile dysfunction... 

A 12-year-old boy with prostatic rhabdomyosarcoma had episodes of syncope periodically over 7 months while taking fluconazole for chemotherapy-induced mucositis. He had taken fluconazole in the past without problems but had also taken a stable dose of amitriptyline for neuropathic pain. On withdrawal of amitriptyline he had no further episodes. The effect was confirmed by re administration. 

Interleukin-1-alfa can cause mucositis and xerostomia (3) and can increase the severity of chemotherapy-induced oral mucositis and erythema (5). 

In gastrointestinal disease Peptic ulceration Liver transplantation Chemotherapy-induced mucosal lesions... 

Elting LS, Cooksley C, Chambers M et al (2003) The burdens of cancer therapy clinical and economical outcomes of chemotherapy induced mucositis. Cancer 98 1531-1539... 

Systemic azole agents are used for treating OPC in patients who have failed or who are unable to take topical therapy. The preceding discussion on the relative efficacy of fluconazole, itraconazole, and ketocoanzole in HIV-infected patients may be extrapolated to the non-HIV-infected population. Fluconazole 100 to 200 mg daily is used more commonly because of more extensive experience with its use, and it is more effective and has a more favorable absorption and side-effect profile compared with ketoconazole. If the oral route is not feasible for reasons such as severe chemotherapy-induced mucositis, fluconazole may be administered intravenously. In patients mire-sponsive to azoles, intravenous amphotericin B in relatively low doses... 

Sorensen JB, Skovsgaard T, Bork E, Damstrup L, Ingeberg S. Double-blind, placebo-controlled, randomized study of chlorhexidine prophylaxis for 5-fluorouracil-based chemotherapy-induced oral mucositis with nonblinded randomized comparison to oral cooling (cryotherapy) in gastrointestinal malignancies. Cancer 2008 112(7) 1600-6. 

Wardill HR, Bowen JM, Gibson RJ (2013) Biomarkers of small intestinal mucosal damage induced by chemotherapy an emerging role for the 13C sucrose breath test. J Support Oncol ll(2) 61-67... 

G. Other applications Neupogen may also be useful in preventing opportunistic diseases in patients infected with the human immunodehciency virus and for drug-induced agranulocytosis. The use of topical hlgrastim may be effective in reducing oral mucositis due to intensive chemotherapy. 

In a retrospective analysis over 13 years of cytostatic therapy for various conditions there were 12 cases in which chemotherapy had caused gastrointestinal perforation (43). Six doses of etoposide each of 250 mg/m induced an advanced stage (grade 4) of mucositis. Fifty percent of patients receiving epirubicin 120 mg/m ... 

Sonis ST, Eilers JP, Epstein JB, LeVeque FG, Liggett WH Jr, Mulagha MT, Peterson DE, Rose AH, Schubert MM, Spijkervet FK, Wittes JP. Vahdation of a new scoring system for the assessment of clinical trial research of oral mucositis induced by radiation or chemotherapy. Mucositis Study Group. Cancer 1999 85(10) 2103-13. 

In yet another report of suxamethonium-induced fatal hyperkalemic cardiac arrest in an intensive care unit it was assumed that severe mucositis after cancer chemotherapy might have contributed to the hyperkalemic response (197). 

Al-Khafaji AH, Dewhirst WE, Cornell CJ Jr, Quill TJ. Succinylcholine-induced hyperkalemia in a patient with mucositis secondary to chemotherapy. Crit Care Med 2001 29(6) 1274-6. 

Oral mucositis induced by radiation and breaks in physical barrier of oral epithelium, which is protective against invasion by microorganisms altered rate of mucosa regeneration by cancer chemotherapy, which increases vulnerability to infection. 

Howarth GS, Tooley K, Davidson G, Butler RN (2006) A noninvasive method for detection of intestinal mucositis induced by different classes of chemotherapy drugs in the rat. Cancer Biol Ther 5 1189-1195... 

C.E. Saadeh, Chemotherapy- and radiotherapy-induced oral mucositis Review of preventive strategies and treatment, Pharmacotherapy, 25 (4), 540-554,2005. 

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