Mucosal tolerance induction

Mucosal tolerance protection from hypersensitivity reactions towards harmless environmental and food antigens Mucosal homeostasis induction of immunoregulatory functions, maintenance of an intact endogenous micro flora... 

Winkler B, Baier K, Wagner S, Repa A, Scheiner O, Kraft D, Wiedermann U Mucosal tolerance induced in primed mice is long-lasting independent of the time of induction. Allergy 2002 57 (suppl 75) 31. 

Hufhagl K, Winkler B, Focke M, Baier K, Valenta R, Kraft D, Wiedermann U Induction of mucosal tolerance by coapplication of recombinant Bet v 1, the major birch pollen allergen, recombinant Phi p 1 and Phi p 5, major grass pollen allergens, in polysensitized mice. Allergy 2002 57(suppl 73) 49. 

Wiedermann U, Kraft D Induction of mucosal tolerance to Bet v 1, the major birch pollen allergen, a review. Allergy Clin Immunol Int 2002 14 17-24. 

It is of particular clinical relevance to test the effects of mucosal allergen application in already sensitized organisms. The obvious advantage of the use of so-called hypoallergenic molecules lies in their risk-free application. Thus, the practical consequences from such experimental studies could include the development of low-risk mucosal vaccines based on the induction of tolerance - with or without the use of certain mucosal antigen delivery systems. 

Mucosal adjuvant and vaccine delivery system development is an area of importance for improving public health. Mucosal immunization can serve in the future in increasing mucosal immune function, induction of protective immunity against infections, and induction of tolerance or modifying autoimmune disorders, allergies, and autoimmune diseases. Development of oral vaccines would have large implications for rural and remote populations where access to trained medical staff to administer vaccines by injection can be lacking. 

Induction of tolerance Change in mucosal environment 2 No May be useful in treatment of allergic disorders May not predict potential for disease... 

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