Mucosal tolerance

Hanninen A, Harrison LC "y8 T cells as mediators of mucosal tolerance the autoimmune diabetes model. Immunol Rev 2000 173 109-119. 

The second part describes the regulation and immunological events in different allergic diseases, such as asthma and atopic skin diseases, in parasite infection and delayed-type hypersensitivity. Special attention is paid to mucosal tolerance, which is important in many respects including... 

MALT Mucosal vaccination Mucosal tolerance Nasal/oral inhalation Treatment agent allergies Hyperresponsiveness... 

Mucosal tolerance protection from hypersensitivity reactions towards harmless environmental and food antigens Mucosal homeostasis induction of immunoregulatory functions, maintenance of an intact endogenous micro flora... 

Mucosal tolerance is a meanwhile well-accepted phenomenon, which was initially referred to as oral tolerance , because it was first recognized after feeding antigen [14], As immunological unresponsiveness - characterized by a refractory or diminished capability to develop an immune response upon systemic reexposure to the specific antigen - can also be achieved after antigen administration via the nasal, inhalative, rectal or genital route, it is now more broadly referred to as mucosal tolerance. 

Table 2. Examples of experimental models using mucosal tolerance as treatment strategy... 

Winkler B, Baier B, Wagner S, Repa A, Scheiner O, Kraft D, Wiedermann U Mucosal tolerance as therapy of type I allergy Intranasal application of recombinant Bet v 1, the major birch pollen allergen, leads to the suppression of allergic immune responses and airway inflammation in sensitized mice. Clin Exp Allergy 2002 32 30-36. 

Hufhagl K, Winkler B, Focke M, Baier K, Valenta R, Kraft D, Wiedermann U Induction of mucosal tolerance by coapplication of recombinant Bet v 1, the major birch pollen allergen, recombinant Phi p 1 and Phi p 5, major grass pollen allergens, in polysensitized mice. Allergy 2002 57(suppl 73) 49. 

Wiedermann U, Kraft D Induction of mucosal tolerance to Bet v 1, the major birch pollen allergen, a review. Allergy Clin Immunol Int 2002 14 17-24. 

Takeda H, Spatz M, Ruetzler C, McCaiTon R, Becker K, Hallenbeck J (2002) Inducdon of mucosal tolerance to E-selecdn prevents ischemic and hemon liagic sdoke in spontaneously hypertensive genedcally sdoke-prone rats. Sdoke 33 2156—2163. 

Keywords Adaptive iimnunity Copolymer-1 (Copaxone or gladramer acetate) Immune boost Immune modulation Immune suppression Mucosal tolerance Nasal tolerance Oral tolerance T cell vaccination Vaccination... 

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