Mucat

Prepared by heating ammonium mucate, or from butyne-l,4-diol and ammonia in the presence of an alumina catalyst. The pyrrole molecule is aromatic in character. It is not basic and the imino-hydrogen atom can be replaced by potassium. Many pyrrole derivatives occur naturally, e.g. proline, indican, haem and chlorophyll. 

Hamielec, A.E., Computer Applications Modeling of Polymer Reactor Systems , Proceedings - Polymer Characterization Conference, Cleveland State University. Division of Continuing Mucation, Qeveland, Ohio, April 30 - May 1, 1974. 

Ammonium mucate is heated with an equal weight of glycerol yields of 40 52 per cent of the theoretical amount are... 

Midrin is a proprietary combination of acetaminophen, isometheptene mucate (a sympathomimetic amine), and dichloralphenazone (a chloral hydrate derivative) that has shown modest benefits in placebo-controlled trials. It may be an alternative for patients with mild to moderate migraine... 

Pyrrole from Ammonium Mucate.3—Mucic acid (15 g.) is dis-... 

Related substance present in good number of official drugs may be determined by GLC method, for instance Bromopheneramine maleate Bronopol Cepahloridine Chlorocresol Chloroform Chloroxylenol., Cindamycin hydrochloride Griseofulvin Isometheptene mucate Levomenthol ... 

Based on a review of this drug (isometheptene mucate) by the National Academy of Sciences-National Research Council or other information, FDA has classified the other indication as possibly effective in the treatment of migraine headache. Final classification of the less-than-effective indication requires further investigation. 

Pharmacoiogy Isometheptene mucate acts by constricting dilated cranial and cerebral arterioles, thus reducing the stimuli that lead to vascular headaches. Dichloralphenazone, a mild sedative, reduces the patient s emotional reaction to the pain of both vascular and tension headaches. 

Capsules-. Acetaminophen 325 mg, isometheptene mucate 65 mg, dichloralphenazone 100 mg (I.D.A, Midrin, Migrin-A). 

Vidaver, G.A. (1964a). Mucate inhibition of glycine entry into pigeon red cells. Biochemistry 3, 799-803. 

Midrin is mixture of a mild blood vessel constrictor called isometheptene mucate, a mild sedative called dichloralphenazone, and acetaminophen. It is mostly used to treat mild migraines. Only mild dizziness and skin rash have been reported as side effects. 

Neosal (Nordmark)-comb. wfm J Cesal (Dainippon)-comb. Midrin (Camrick as mucate)... 

Pyrrole can be obtained by fractional distillation of bone oil and purification through the potassium derivative.1 The only synthetic method offering any possibilities involves the thermal decomposition of ammonium mucate, either alone 2 or in presence of glycerol.3... 

Midrin is a proprietary combination of acetaminophen, isometheptene mucate (a sympathomimetic amine), and dichloralphenazone (a chloral... 

Dose. Isometheptene mucate has been given in doses of up to 520 mg daily. 

Denatonium Benzoate 467.5 Saccharin Calcium 492.7 Isometheptene Mucate... 

The presence of mucic acid in wine causes calcium mucate crystals which are formed during prolonged storage when wine contains >0.1 g/L mucic acid. This level is reached when 10-25% of the grapes used are infected with B. cinerea (Wuerdig 1977). 

A very convenient and versatile new reduction method, which has been intensively studied for the reduction of thiophenes (vide infra), makes use of the combination of a trialkylsilane and an acid, usually trifluoroacetic acid (TFA). This so-called ionic hydrogenation provides a novel reduction of furans to tetrahydrofurans (Scheme 3). Although Bolestova et al. find that the conditions are critical in order to avoid polymerization, the yields of tetrahydrofurans can be quite good. The reduction is accelerated by the presence of boron trifluoride etherate but fails with carbonyl-substituted furans, such as methyl pyro-mucate. ... 

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