Monofluoro phosphate

For Py.POpCl (la) the product consists of monofluoro-phosphate i75 %) and monophosphate (25 ). It is probable that initially formed LPO3I" (cf. eq. (5)) rapidly reacts with F to [P03FJ2 (S.,1(P)). 

Fluorine (F) Fluorine is a yellowish, poisonous gas. In its natural state it is a diatomic molecule, F2. Sodium fluoride is added to drinking water to strengthen teeth. Other fluoridation sources include sodium monofluoro-phosphate and stannous fluoride. The polymer of tetrafluoroethylene is a strong, slippery solid known as Teflon . 

FPOaKj Potassium monofluoro-phosphate, 3 109 FPOa(NHj)j Ammonium mono-fluorophosphate, 2 155 FPOaNas Sodium monofluoro-phosphate, 3 106, 108 F2Ag Silver(II) fluoride, 3 176 F2Ca Calcium fluoride, 4 137 FjHg Mercury(II) fluoride, 4 136 F2KH Potassium hydrogen fluoride, 1 140... 

FPO3K2 Potassium monofluoro-phosphate, 3 109 FPOs(NH4)2 Ammonium mono-fluorophosphate, 2 155... 

Fluoride in dentrifices is usually present as sodium fluoride or monofluoro-phosphate or tin(II) fluoride [192,313,341,358,359]. Analysis of aqueous extracts or slurries of such dentrifices take less than 10 min with the fluoride electrode and closely match those obtained by a diffusion—thorium(IV) titration method but which requires about 45 min per sample [358]. 

Studies with rats, human adults and some children indicate that calcium-based polishing agents in five commercial and four experimental toothpastes prevent gut absorption of a considerable fraction of fluoride and monofluoro-phosphate owing to complexation [192]. Except for small initial losses of uncomplexed fluoride by interaction with calcium carbonate polishing particles, no major depletion of active ionic fluoride is found to occur in toothpastes over one year [359] but another study indicated considerable losses of free fluoride after only four months of shelf life [341]. It should be noted that analysis with the fluoride electrode might be unreliable in samples containing monofluoro-phosphate [360], glycerin [313] and silica gel [313]. 

PO4 (polyphosphate, monofluoro phosphates) Photodiode array detection [333]... 

Nieschalk, J., Batsanov, A.S., O Hagan, D., and Howard, J.A.K., Synthesis of monofluoro- and difluoromethylenephosphonate analogs of A w-glycerol-S-phosphate as substrates for glycerol-3-phos-phate dehydrogenase and the X-ray structure of the fluoromethylenephosphonate moiety. Tetrahedron, 52, 165, 1996. 

Halogenoalkyl and Related Acids. In view of their extensive applications as, for example, phosphate mimics, new routes to a-mono- and -di-fluoroalkylphos-phonates are always welcome and during the period of this review a substantial number have been reported. A variety of functionalised examples of such compounds have been prepared from the readily available difluorophosphonate (188). ° For example, the monofluoro analogue (191) of serine phosphate has been synthesised by the reaction of (188) with organocopper reagents to give (190) followed by reduction and further functionalisation (Scheme 28). The... 

However, the monofluoro analog 12 has been made the enzyme itself will assemble it fiom Z-fluoro-PEP and S-3-P, as Mark Walker and the Monsanto group have recently shown (Figure 9).3 Actually, EPSP synthase induces formation of 12, it doesn t catalyze it This analog is a powerful inhibitor and the enzyme can t carry it further to fluoro-EPSP thus, turnover and true catalysis do not occur. We have tried to get to this monofluoro derivative fiom the other direction, namely from Z-fluoro-EPSP, but the enzyme will not oblige us. Enzymatic formation of 12 from S-3-P and Z-fluoro-PEP takes less than a minute, but even weeks of incubation of enzyme, phosphate, and Z-fluoro-EPSP give no evidence for formation of 12 or Z-fluoro-PEP.37... 

A number of deoxy-, dideo y-monofluoro-, and dideoxy-difluoro-o-D-glucopyranosyl phosphates have been prepared for a comparative study of their acid hydrolysis rates. As in the hydrolysis of alkyl glycosides, deoxy derivatives reacted faster and fluorinated analogues much slower than the parent 1-phosphates, and it was concluded that the transition states for the hydrolysis of glycosides and glycosyl phosphates are essentially identical. ... 

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