Moisture content critical, defined

Further, since the addition of moisture in the agglomerator is an important tool to control growth (see Section 7.2) and other agglomeration parameters, the feed moisture should be several percentage points below the critical maximum moisture content, as defined above. The moisture content is less critical in fluidized-bed agglom-erators which also act as dryers. Here, the moisture must often be high enough to make the feed pumpable (see Section 7.4.4). 

In a later work, Albrecht [65] showed that characteristic drying curves could be drawn up for the through-circulation drying of cottonlike fabrics over a range of incident velocities from 0.1 to 0.6 m s The critical moisture content was defined by the intersection of the constant rate and linearized falling rate curves. One has... 

Additionally, the process should be controlled by employment of a validation protocol, which defines the critical parameters and also establishes the acceptance criteria for the granulation or blend and which may include sieve analysis, flow, density, uniformity and compressibility, moisture content, etc. 

Thermal analysis data also dictate the maximum product temperature allowable during primary drying. Shelf temperatures and chamber pressures are then selected to assure that the product remains below this critical threshold temperature during primary drying. Secondary drying conditions necessary to achieve the desired residual moisture content are also identified. Determination of these processing parameters requires numerous process studies and corresponding stability studies to define optimal conditions. 

Seed moisture is normally expressed as weight percentage of the whole seed. As water is insoluble in seed lipids, the moisture content is concentrated in the nonfatty parts of the seed. The water content calculated on a nonfatty basis is defined as critical moisture. The critical moisture of sunflower seeds is 16%, although a maximum 15% is recommended for storage. 

The first stage of drying involving shrinkage is not always separated from the subsequent stage by an explicitly defined critical moisture content (point B in Fig. 170) and the rate of water removal in this stage is not quite constant. 

In another method an approximate straight line from the critical free moisture content to the origin at zero free moisture was assumed. Here the rate of drying was assumed to be a linear function of the free moisture content. The rate of drying R is defined by Eq. (9.5-3). 

Initiation of pitting corrosion takes place when the chloride content at the surface of the reinforcement reaches a threshold value (or critical chloride content). A certain time is required from the breakdown of the passive film and the formation of the first pit, according to the mechanism of corrosion described above. From a practical point of view, the initiation time can be considered as the time when the reinforcement, in concrete that contains substantial moisture and oxygen, is characterized by an averaged sustained corrosion rate higher than 2 mA/m [8], The chloride threshold of a specific structure can be defined as the chloride content required to reach this condition of corrosion. 

QbD on stability studies are science and risk-based approach to understanding API physical and chemistry properties. The API s KSAs are typically moisture, solvent content, impurities, polymorph, particle size, stoichiometry, and other attributes specific to the individual API. Risk-based criticality analysis of these KSAs can address their potential influence on the API stability, therefore, help to define the API stability control strategy. " °... 

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