Shelf temperature

Fully Processed Foods. Fully processed foods are processed and packaged so that the ambient temperature shelf life can exceed three to six... 

Atmospheric (a) or vacuum (b) Drying temperature material (°F) Drying temperature shelf (°F) Bulk density product (lb/ft3) (b) 26 Hg (a) 60 lb/in.2/gauge 153C (b)... 

Nail investigated the effect of chamber pressure on heat transfer and the relative rate of sublimation. Chamber pressure has a prominent effect on product temperature. Shelf temperature is the principal influence on sublimation rate chamber pressure has a strong influence on heat transfer from the shelf to the vial and the relative difference between the vapor pressure of ice and the environment. The combined effects yield a direct impact on product temperature. The driving force of sublimation is the difference between the vapor pressure of ice in the product and the pressure of the environment. An increase in the differential increases the propensity of ice to sublime. For example, if the product temperature is 32°C with a corresponding vapor pressure of ice being 321 pHg... 

Diltiazem undergoes hydrolysis to desacetyl diltiazem in aqueous buffer solutions (pH 1-7) (35). Diltiazem is most stable at pH 5. The decomposition follows pseudo-first order kinetics. The extrapolated room temperature shelf-life was 42 days or 15.8 days at pH 5 or 2, respectively. Exposure of aqueous buffered solutions of diltiazem at pH 2 or 7 to UV radiation caused more degradation as compared to the same solutions protected from light, demonstrating the light sensivity of the compound in solution (34). The stability of diltiazem hydrochloride in aqueous sugar solutions (fructose, dextrose, sucrose, sorbitol and mannitol) was determined to be superior to that in pH 5 aqueous buffer (36). 

Calculations using Arrhenius plots, such as those described above, are carried out in the pharmaceutical industry every day. It should be made clear, however, that they involve a number of assumptions. It is assumed that the linearity of the graph obtained from equation (9.9) extends to room temperature, or, mathematically, that A and E are independent of temperature. If the line cannot be extrapolated to room temperature, shelf-life predictions are invalid. Second, it is assumed that the same chemical reaction is occurring with decomposition at high temperature as at low temperature. This is usually the case, but until proven it remains an assumption in most calculations. 

Leuprolide, used for the palliative treatment of prostate cancer, was formulated at 370 mg/ml in DMSO within an osmotically-driven implantable pump lasting 1 year, where the choice of DMSO provided 2 year room temperature shelf life, plus 1 year of implant life at 37°C (Stevenson et al., 1999 Wright et al., 2001). 

The thermal initiator is benzopinacol (4), which is stable at room temperature (shelf-life of the uncured liquid conformal coating is more than 6 months at room temperature), but which undergoes a homolytic cleavage upon heating to form diphenylhydroxy-methyl radicals (Equation 2), which are believed to initiate polymerization by hydrogen atom transfer to the double bond of the acrylate (Equation 3) (9). 

Storage configurations, maximum quantities, and minimum/maximum storage temperatures Shelf life considerations What to do in the event of a leak or spill What to do if an unwanted reaction starts How to fight a fire involving the material... 

An ideal epoxide moulding compound would have indefinite shelf stability at room temperature. Unfortunately it is not possible to have a compound that will cure in 90 s at 180°C and yet will not react at room temperature. Shelf stability of epoxide moulding compounds is... 

Increase or room temperature shelf life to 18 months. 

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