MITI test

Training (acyclic) n = 47 Overall 85% correct (92% for easily degrad.) (79% for non-easily degrad.) Validation (acylic) n = 240 (MITI test) Overall 89% correct (97% for easily degrad.) (61% for non-easily... 

Training (monocyclic arom.) n = 60 Overall 85% correct Validation (monocyclic arom.) n = 57 (MITI test) Overall 84% correct (87% for easily degrad.) (83% for non-easily degrad.)... 

Degner et al. (1993) used the model with a dataset of 774 chemicals with MITI test data and found 80.7% correct estimates for easily degradable/non-degradable classifications. They were unable to classify 18 chemicals due to a lack of indicator variables. 

The Acyclic Aliphatic and Monocyclic Aromatic models were developed during an evaluation of other biodegradation prediction models. As Table 12.6 indicates, the two models were developed with seven structural fragments (acyclic aliphatic) and nine structural fragments (monocyclic aromatic) by means of discriminant analysis with MITI test data. 

Ready MITI test (67/548/EEC) EC V.C. 4-F OECD 301C o2 60% or greater... 

OECD Test Guideline 302C (1981). Inherent biodegradability Modified MITI test (II). OECD guidelines for testing of chemicals... 

Ready Biodegradability A DOC Die-Away Test B C02 Evolution Test C Modified MITI Test (I)... 

C Inherent Biodegradability Modified MITI Test (II) (original guideline, adopted May 12, 1981)... 

Solubility In natural systems, microbes produce emulsifiers that render insoluble matter accessible for degradation. All of the systems currently available were developed for water-soluble materials and, although the use of artificial solvents or emulsifiers is permitted in the test guidelines, their use is restricted to 100 ppm in tests related to ecotoxicology and product classification, and neither is permitted in the MITI test. This approach is, in most cases, ineffective with oils since much higher concentrations are needed to achieve solubility, which renders the conditions of the test doubtful. 

OECD 302C, 1993, Inherent biodegradability Modified MITI Test (11) - 302 C. Guidelines for testing of chemicals. Organization for Economic Cooperation and Development (OECD), Paris, France. 

OECD 30IC (Modified MITI test - Ready degradability test)... 

C Moditied MITI Test (II) Guidelines for simulation tests WA Indirect, via BOD and DOC or direct analysts of residual chemicals No Yes... 

OECD 301C, Ready Biodegradability Test, Modified MITI Test, 1992. 

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