Ready biodegradation

Consequently, it is generally accepted that the chemical nature of the hydrophilic group affects biodegradability to a minor extent and that the hydrophobic group is the responsible for a ready biodegradation. 

Stein and Baumann [14] studied the hydrolytic stability of MES and found the hydrolysis rate to be very slow in the pH range of 3-9.5 even at a temperature of 80°C. MES possesses good washing, foaming, and lime soap dispersing properties as well as ready biodegradability and a low acute oral toxicity. 

Hanstveit R (2003a) Trichloromethylstannane (CAS 993-16-8) Determination of the ready biodegradability in a manometric respiration test Delft, TNO, September (Repert Ne. V2492/01). 

Hanstveit R (2003f) Determination of the ready biodegradability of dichlorodioctylstannane in a manometric respiration test. 

Ready biodegradability refers to the situation in which the test compound is totally degraded (under aerobic conditions to COj, HjO, etc.) within the time span of a standardized test usually lasting 5, 7, or 28 d. 

Figure 9.5 Conventional (a) and sustainable approach for the design of new pharmaceuticals (b) [103]. After-use life depends on many unknowns related to fate and effects of compounds. Ready biodegradability at least mitigates this problem.

Table 9.1 Biodegradability (in %) of selected pharmaceuticals from various classes in different OECD tests (Kiimmerer and co-workers, unpublished work) [46, 99, 106, 110]. Criterion for ready biodegradability in 301 tests and inherent biodegradability in 302 tests is > 60%.

Rorije, E. and Struijs, J. (1999) Prediction of biodegradability from chemical structure modeling of ready biodegradation test data. Environ. Toxicol. Chem., 18 (8), 1763-1768. 

Evaluation and application of models for the prediction of ready biodegradability in the MITI-I test. Chemosphere, 38 (6), 1409-1417. 

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