Minimum required performance levels

World Anti-Doping Agency (2009) Minimum Required Performance Limits for DetectionofProhibitedSubstances.A ailableathttp ll mv/.w i[Pg.60]

Due to the obtained purity of the urine extracts combined with the high resolution and accurate mass capability of the analytical instrumentation, 72 stimulants and metabolites, 21 narcotics and metabolites, 10 P2-agonists, and 31 P-blockers are, besides numerous additional compounds, simultaneously detected at minimum required performance levels. ... 

Theoretical Performance Requirements. Each propulsion system has a minimum performance level that must be achieved to conduct its required mission. After careful analysis of the mission profile, this required performance level is usually related in terms of required specific thrust or specific impulse (I8). This nomenclature defines the pound of thrust produced per pound per second of propellant flow ... 

A major factor affecting the quality of the final result is the suitability of the analytical method applied. Ensuring that the method is fit for purpose can be considered a basic quality control criterion. It is important that laboratories restrict their choice of methods to those that have been characterized as suitable for the matrix and analyte of interest, and at the level of interest. In the EU, and in many other countries and regions, the regulatory limit for authorized veterinary medicinal products is the maximum residue limit (MRL), and for contaminants the maximum permitted limit. Eor prohibited or unauthorized analytes, there is often a threshold or action limit set in Europe, for example, the appropriate regulatory limit is the minimum required performance limit (MRPL) or the reference point for action (RPA), as defined in Article 4 of Commission Decision 2002/657/EC, Article 2 of Commission Decision 2005/34/EC, and Articles 18 and 19 of Council Regulation (EEC) 470/2009.2 ... 

Methods are validated using samples fortified with the analyte of interest at appropriate levels (i.e., normally levels similar to levels found in the samples), levels related to MRLs for permitted substances, or levels related to minimum required performance limits for prohibited or unapproved substances. Following validation of the method and its... 

Once a catalyst that meets the minimum required performance standards is identified, the research effort is then shifted from discovery toward a development type of activity as shown in the middle cycle. Hence, more detailed evaluation of the catalyst candidates is conducted using a more sophisticated reactor system. This system should be designed so it can provide experimental data that can be used as the basis for discrimination between various proposed kinetic mechanisms and the associated kinetic rate parameters. It should also be crqrable of providing information on catalyst activity versus time-on-stream for quantifrcation of catalyst deactivation. Since the cost of periodic catalyst replacement or regeneration to maintain plant productivity can have a significant impact on process economics, information on catalyst activity and the catalyst performance parameters over a range of activities is critical for identifying more precise catalyst research milestones. If the minimum required level of catalyst performance versus time-on-stream is not attained, it may be necessary for additional discovery work to be undertaken. 

Commission Decision 2002/657/EC [12] defines the performance criteria for analytical residue methods and is probably the key document of legislation to be consulted by residue control laboratories. This reference document introduces the concept of the minimum required performance limit (MRPL) for compounds belonging to Group A it corresponds to the minimum content of an analyte in a sample that has to be detected and confirmed, and it constitutes the lowest level that can be reliably considered "nonzero."... 

Most laminated glass appHcations are concerned with impact strength, and minimum performance levels are required by specification. The impact strength of two pHes of laminated, aimealed glass and various PVB thicknesses are available (4). Aircraft laminates may utilise electrical resistance heating as deicing for vision enhancement. 

Quantitative controllable variables are ftequentiy related to the response (or performance) variable by some assumed statistical relationship or model. The minimum number of conditions or levels per variable is determined by the form of the assumed model. For example, if a straight-line relationship can be assumed, two levels (or conditions) may be sufficient for a quadratic relationship a minimum of three levels is required. However, it is often desirable to include some added points, above the minimum needed, so as to allow assessment of the adequacy of the assumed model. 

Most hydrocarbon facility process areas and high volume storage areas have standardized on a minimum supply or availability of four hours of firewater for the WCCE. The performance of risk analysis may reveal the level of fire water protection may be more or less than this requirement. Once a detailed design is completed on a facility or if a verification of existing water demands is needed, a simple tabular calculation of firewater requirements can be made. This table can be used to document spray density requirements, duration levels, code requirements and other features. Table 23 provides and example of arrangement to document such information. 

A calibration curve is a graph on which concentration is plotted along the x-axis and analytical response is plotted along the y-axis. The line connecting the points represents tlie calibration curve. The calibration curve study is generally performed by preparing standard solutions at five concentration levels, from 50 to 150% of the target analyte concenlration. A minimum of five levels is required to allow detection of curvature in the plotted data. 

Standard operating procedures (SOPs) are written procedures that describe how to perform basic operations in a plant. They explain certain minimum requirements to assure that there is a level of control... 

Appendix. There are also minimum performance requirements for each classification that are defined in terms of performance in prescribed engine tests. The minimum performance levels in those tests are at least equal to those required to meet the standard. This approach will provide the user with better assurance that oil marketed as being suitable for a particular service classification is suitable. 

Individuals who perform data checking must be trained in data accuracy as a minimum requirement. Additional training may be necessary as appropriate to the level of checking being performed. 

Tests made with pure asphalt (formulation 1A, semi-crushed) gave results slightly better than those for corresponding 2 S/A formulations. With the 3 S/A formulation, using only round material and no filler, the minimum performance level required for a surface layer was just reached, with allowance for the possible effect of ageing. The results, as a whole, are better than those for the 2 S/A formulation. The corresponding pure asphalt 2A formulation does not attain the minimum values. 

The purpose of the study is to provide a minimum safety integrity level of HIPPS for determination of required risk reduction performance. A systematic approach and an example to assign the acceptable safety level of a pilot HIPPS model are proposed based on the LOPA. 

Note 2 The maximum and minimum performance levels are dictated by the requirements of the MoD performance specifications DTD 5629-33 inclusive - except in the case of 5633 where no upper limit is set. In the diagram the usual performance figure is given (see Figure 2.13). 

The minimum requirements for this type of work will depend on the type of testing and calibration being performed. However, because much of it relates to radiation protection instruments the actual neutron flux and gamma radiation level requirements are quite low. Dose rate levels from a few micro-Sv h to a few milli-Sv h are often all that is necessary. 

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