Minimum lethal concentration, dose

Toxicity. The estimated minimum lethal oral dose is 30 ml the maximum permissible atmospheric concentration is 400 ppm. Atmospheric concentrations of 2000 ppm may cause dizziness and 100 000 ppm may be rapidly fatal. 

The principal hazard of concentrated -butylamine to human health is its capacity to produce severe burns of the skin and eyes, as well as respiratory tract irritation (the maximal effect being pulmonary edema). Harm may occur due to direct contact with liquid or vapor at sufficiently high concentrations. Signs of toxicity include tissue damage at the site of contact, sedation, ataxia, nasal discharge, gasping, and salivation, followed by convulsions and death at very high doses. A minimum lethal human dose of M-butylamine has not been defined. 

Normal serum concentrations of zinc are in the range 0.7 to 1.7 ag/ml. Zinc salts are considered to be poisonous, but there appears to be no consensus of opinion on the minimum lethal dose. However, fatalities have been recorded following a dose of as little as 10 g of zinc sulphate. A number of suicides have been attempted with eye lotions containing zinc salts. Zinc derived from galvanised pipes occurs as a contaminant of drinking water. 

Toxicity. The estimated minimum lethal dose is 5 ml and the maximum permissible atmospheric concentration is 10 ppm. 

Toxicity. Severe symptoms may follow absorption of 1 to 3 g the estimated minimum lethal dose is 5 g. The maximum permissible atmospheric concentration is 0.25 mg/m and the maximum permissible concentration in food is 0.1 ppm. 

Toxicity. The estimated minimum lethal dose in non-addicted adults is 200 mg. Toxic effects may be produced with blood concentrations of 0.2 to 3 pg/ml, and fatalities with concentrations greater than 0.5 pg/ml. Deaths from overdosage are comparatively rare. 

Toxicity. The estimated minimum lethal dose is 1.5 g. Toxic effects are associated with plasma concentrations greater than 9 pg/ml and fatalities with postmortem blood concentrations of 9 to 26 to 72 pg/ml. 

Toxicity. The minimum lethal dose may be as low as 1 g although recovery has followed the ingestion of 30 g. Serious toxic effects may occur after exposure for about 1 hour to atmospheric concentrations of 100 to 160 ppm. The maximum permissible atmospheric concentration is 2 ppm. Urinary concentrations of greater than lOpg/ml of 4-aminophenol may indicate toxic exposure to aniline. 

Toxicity. The estimated minimum lethal dose is 2 g. Plasma concentrations greater than 40 ig/ml are usually associated with toxic effects concentrations greater than 50 pg/ml may be fatal. In 4 cases of death attributed to overdoses ranging from 2.5 to 7.7 g, antemortem serum concentrations ranged from 120 to 150gg/ml. In 44 cases of overdose in which the patients subsequently recovered, the serum concentrations 24 hours after ingestion were in the range 40 to 130 pg/ml (P. Lous, Acta pharmac. tox., 1954,10, 261-280). 

Toxicity. The estimated minimum lethal dose is 15 g. Plasma concentrations of salicylic acid greater than 300 pg/ml are likely to produce toxic reactions and concentrations greater than 500 pg/ml are associated with moderate to severe intoxication. The maximum permissible atmospheric concentration is 5 mg/m. ... 

Toxicity. The estimated minimum lethal dose is 5 g. Plasma concentrations of 2.4 to 6.0 to 10.5 pg/ml have been associated with slight toxic effects and concentrations of 3.2 to 10 to 21 pg/ ml with severe toxicity. 

Toxicity. The minimum lethal dose is 10 ml by ingestion and the maximum permissible atmospheric concentration is 10 ppm. Exposure to air concentrations of 100 to 1000 ppm for short periods may cause discomfort and dizziness and concentrations of 7000 ppm or more will produce rapid loss of consciousness. The following postmortem tissue concentrations were reported in 7 fatalities blood 10 to48 pg/ml (mean 32, 7 cases) brain 50.4 to 156pg/g (mean 101, 4 cases) kidney 16 to 27 pg/g (mean 20, 3 cases) liver 6 to 86.2 pg/g (mean 43.4, 6 cases) urine 0 to 60pg/ml (mean 15, 5 cases) (R. Bonnichsen and A. C. Maehly, J.forens. Sci., 1966, 11, 414-427 and G. V. Giusti and M. Chiarotti, Medicine, Sci. Law, 1981,27, 2-3). 

Toxicity. The estimated minimum lethal dose is 1.2 g but susceptible persons have died from doses as small as 30 mg when applied to mucous membranes addicts may be able to tolerate up to 5 g a day. Toxic effects have been noted with blood concentrations in the range 0.25 to 5 pg/ml and fatalities have occurred with concentrations of 1 pg/ml or more. 

Toxicity. The estimated minimum lethal dose is 0.5 g. Blood concentrations in the region of 1 pg/ml are likely to cause toxic reactions concentrations of 2 pg/ml or more may be lethal. In fatalities in which dextropropoxyphene is involved, it is common to find much greater concentrations in the liver and lungs than in the blood. Addicts can ingest 10 times the normal dosage before showing toxicity whereas children show toxic symptoms after only one-twentieth of the normal dose. 

Toxicity. The estimated minimum lethal dose is 30 g but a single oral dose of 10 mg/kg may produce toxic symptoms the maximum permissible atmospheric concentration is 1 mg/m and the maximum acceptable daily intake is 5 pg/kg. The toxicity of some of the organic solvents, such as kerosene, used in the application of dicophane has probably contributed to dicophane fatalities. 

Toxicity. Doses in excess of 500 mg are likely to produce severe toxic effects and the estimated minimum lethal dose is 1 g. Blood concentrations greater than 0.1 pg/ml may be associated with toxic reactions and fatalities have been associated with blood concentrations of 1 to 8 to 18 pg/ml. 

Toxicity. The minimum lethal dose is about 500 ml of 50% v/v spirit ingested in about 1 hour. In the United Kingdom it is illegal to be in charge of a motor vehicle with a concentration greater than 800 pg/ml in the blood or 1070 pg/ml in the urine or 35 pg/ml in the breath. Toxic effects are associated with blood concentrations of 840 to 2400 to 4500 pg/ml, and subjects with concentrations of 3000 pg/ml or more are considered to be clinically drunk. Blood concentrations of 2250 to 4000 to 6030 pg/ ml have been associated with fatalities. The maximum permissible atmospheric concentration is 1000 ppm. 

Toxicity. The estimated minimum lethal dose is 15 g but recovery has occurred after ingestion of as much as 28 g. Prolonged use of ethinamate may lead to dependence of the barbiturate-alcohol type. Blood concentrations greater than 100 pg/ml have been associated with fatalities. 

Toxicity. In adults the minimum lethal dose is probably in excess of 2 g but for young children as little as 200 mg may cause death. Toxic effects may be produced when the plasma concentration is greater than about 0.5 pg/ml, and death has occurred at concentrations above 6 pg/ml. 

Toxicity. Fluoroacetic acid and sodium fluoroacetate are extremely toxic to animals and man the minimum lethal dose is about 5 mg/kg. Toxic effects are delayed for several hours following ingestion or absorption through the skin. The maximum permissible atmospheric concentration is 50 pg/m. ... 

Toxicity. The minimum lethal dose is about 30 ml. Formic acid is dangerously caustic to the skin. The maximum permissible atmospheric concentration is 5 ppm or 9 mg/m the estimated acceptable daily intake is up to 3 mg/kg. 

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