Millennium Pharmaceuticals

Numbers established via 2D search using Chem-X software of compounds listed in World Drug Index, 1999. With thanks to Tim Mitchell and Ryszard Koblecki, Millennium Pharmaceuticals Ltd., Cambridge, UK. 

Mabcampath (EU) or Campath (USA) alemtuzumab a humanized monoclonal antibody directed against CD52 surface antigen of B-lymphocytes) Millennium ILEX (EU) Berlex, ILEX Oncology Millennium Pharmaceuticals (USA) Chronic lymphocytic leukaemia... 

The views expressed in this chapter are solely those of the authors and do not necessarily represent the positions of Hale and Dorr LLP, Millennium Pharmaceuticals, or any related entities. 

Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts 02142 and tBioMolecular Engineering Research Center, College of Engineering, Boston University, Boston, Massachusetts 02215... 

The other compmmd of great interest with a unique mechanism of action is the proteo-some inhibitor bortezumib (Velcade ) (Millennium Pharmaceuticals, Inc., Cambridge,... 

The leptin story has been augmented by a second mouse genetic defect leading to obesity. These mice are known as db/db they are very similar to ob/ob mice. However, these mice have normal levels of leptin. Scientists at Millennium Pharmaceuticals identified the molecular defect in db/db mice. They lack the normal leptin receptor. Therefore, we have both sides of the coin ob/ob mice cannot make leptin, eat too much, and are therefore obese db/db mice make leptin, cannot respond to it for lack of the leptin receptor, eat too much, and are obese. Administration of leptin to ob/ob mice normalizes their body weight but administration of leptin to db/db mice has... 

The group at Millennium Pharmaceuticals has claimed MLN-8054 (97) to be the first kinase inhibitor selective for Aurora-A over Aurora-B, which gives robust inhibition of human tumor xenografts [228-230]. Treatment of cultured human tumor cells with 97 resulted in the accumulation of mitotic cells with spindle abnormalities, a phenotype consistent with selective Aurora-A inhibition. In a pharmacodynamic model the time-dependent accumulation of... 

Bortezomib was kindly provided by Millennium Pharmaceuticals. Prepare a stock solution of 500 pM in Milli-Q sterile water. Store at -20°C. 

Millennium ILEX (EU) Berlex, ILEX Oncology and Millennium Pharmaceuticals (USA)... 

Millennium Pharmaceuticals The Takeda Oncology Company Cambridge, MA... 

Profile The company was founded in 1993. PerSeptive Biosystems is one of its principal investors. In January 1997 it was jointly announced that Millennium Pharmaceuticals would acquire privately held ChemGenics Pharmaceuticals as part of their mutual strategy to become a world leader in drug discovery. Following the merger, the combined company will employ more than 345 people. PerSeptive Biosystems is also a principal ChemGenics shareholder. In August 1997, Perkin-Elmer announced its plans to acquire PerSeptive. 

Department of Drug Metabolism and Pharmacokinetics Millennium Pharmaceuticals Inc. Cambridge, Massachusetts... 

Millennium Pharmaceutical Inc., One Kendall Square Building 300, Cambridge MA, 02139-1562... 

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