Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Micronized crospovidone

The use of Kollidon CL-M as a suspension stabilizer has nothing whatever to do with the principle of increasing the viscosity. The addition of 5-9% has practically no effect in changing the viscosity, but strongly reduces the rate of sedimentation and facilitates the redis-persability, in particular, an effect that is consistent with the low viscosity. One of the reasons for this Kollidon CL-M effect is its low (bulk) density, which is only half of that of conventional crospovidone, e.g. Kollidon CL. It can clearly be seen from Fig. 5 that a relative volume of sediment of normal micronized crospovidone of high bulk density (= Crospovidone M) is less and more compact that of Kollidon CL-M, which undergoes hardly any sedimentation. [Pg.404]

Fig. 5 Volume of sediment of various micronized crospovidone types (7.5% in water + 5% Lutrol F 127)... [Pg.405]

Further, micronized crospovidone is of considerable significance as an active substance against diarrhoea in certain parts of the world. Micronized crospovidone grades of different bulk densities and different applications are available in the market. [Pg.4]

Figure 55 shows the influence of an addition povidone K 90 on the sedimentation behaviour of micronized crospovidone in water at different concentrations. A 7.5% suspension of micronized crospovidone to which 5% povidone K 90 had been added showed no sedimentation within 24 hours, and its redispersibility was very good. Without povidone, significant amounts of crospovidone settled out. [Pg.110]

Fig. 55. Reduction in sedimentation of micronized crospovidone (low bulk density) with povidone K 90... Fig. 55. Reduction in sedimentation of micronized crospovidone (low bulk density) with povidone K 90...
In the case of slightly soluble or practically insoluble drug substances the release can be accelerated not only by reducing the content of PVAc/Povidone but also by the addition of hydrophilic substances like (granulated) lactose, povidone K 30 or micronized crospovidone which act as pore former. [Pg.116]

The particle size distribution of micronized crospovidone can be measured as suspension in water or cyclohexane by a Malvern Master Sizer and there is no significant influence of the solvent. If almost all particles are finer than 50 pm it is classified as Type B of Ph.Eur. [Pg.128]

Fig. 66. Typical particle structure of micronized crospovidone (Ph.Eur. Type B)... Fig. 66. Typical particle structure of micronized crospovidone (Ph.Eur. Type B)...
The crospovidone grades are obtained with different specific surface areas, depending on the polymerization conditions, and their particle size. The micronization process has less influence on the specific surface than small modifications of the polymerization conditions. When a normal crospovidone was micronized the specific surface only increased from l m2/g to i.8 m2/g (N2-BET method). The micronized crospovidone of the lowest bulk density available in the market has the highest specific surface of 2.5 to 6 m2/g (Table 118). [Pg.131]

The swelling pressure of crospovidone varies from grade to grade. Fig. 68 shows the swelling pressures of one of the normal and one of the micronized crospovidone types (lightly compacted 1.5 kN) in three different solvents for comparison. Practically no difference emerged between ethanol and water. [Pg.133]

Table 121. Applications of normal and micronized crospovidone as complexing agent in drugs... Table 121. Applications of normal and micronized crospovidone as complexing agent in drugs...
Crospovidone can contain small quantities of peroxides, within the limits of the specifications, which could theoretically react with drugs in exceptional cases. However, no evidence of this has been found in practice. On the contrary, it has been observed that the vitamins in multivitamin drink granulates were stabilized by micronized crospovidone (see Section 3.4.6.2). [Pg.137]

Stabilization of suspensions by low-density micronized crospovidone as a hydrophilic polymer... [Pg.150]

Differences can be seen not only between the chemically different disintegrants but also between normal and micronized crospovidones, which give very different disintegration times. [Pg.160]

Two different commercial crospovidone types also were compared in analgesic tablets of similar composition to that given in Table 136. Table 139 shows that the disintegration effect of normal crospovidone is many times greater than that of a commercial micronized crospovidone. There was no difference in the hardness of the tablets. The explanation for the difference is to be found in the different swelling characteristics of the two products (see Section 3.2.4). [Pg.160]

Table 139. Comparison of commercial normal and micronized crospovidones in analgesic tablets ... Table 139. Comparison of commercial normal and micronized crospovidones in analgesic tablets ...
It can be concluded that the efficacy of the use of a normal or a micronized crospovidone as disintegrant and dissolution agent depends on the formulation but usually the normal grades disintegrates faster than the micronized grades. [Pg.161]

Micronized crospovidone of low bulk density as a stabilizer for oral and topical suspensions... [Pg.168]

The effect of low-density micronized crospovidone (e.g. Kollidon CL-M) in stabilizing suspensions can also be partly explained in terms of Stokes law Its particle size is very fine (see Section 3.2.2), its bulk density low and its density in water also low as a result of swelling. The product differs in these properties from the coarser products and other micronized types which have a higher bulk density with a similar swelling volume, and make it useful as an auxiliary for oral and topical suspensions for reducing sedimentation and improving redispersibility [98]. The same applies, whether the commercial product is a suspension or a dry syrup, or instant granules from which the patient prepares an oral suspension. [Pg.169]

When micronized crospovidone of low bulk density is used in such suspensions, it is found beneficial in practice to combine it with other auxiliaries such as sodium citrate as an electrolyte, sugar, poloxamer or povidone, to increase the sediment volume. In the example given in Section 2.4.6.2 (Fig. 55), this is done by adding povidone K 90. A suspension of 7.5% of low-density micronized crospovidone with 5% povidone K 90 showed no further sedimentation after a 24-hour test. [Pg.169]

According to the current knowledge the usual concentrations of low-density micronized crospovidone are 5-10% in suspensions. [Pg.169]

To determine the importance of viscosity in suspensions containing micronized crospovidone, the viscosity of an amoxicillin dry syrup (Table 143) was measured at different concentrations. Figure 85 shows that the viscosity hardly changes over... [Pg.169]

Fig. 85. Influence of the concentration of micronized crospovidone of low bulk density on the viscosity of an amoxicillin suspension (Table 143)... Fig. 85. Influence of the concentration of micronized crospovidone of low bulk density on the viscosity of an amoxicillin suspension (Table 143)...
An antibiotic dry syrup formulation is shown in Table 143 as an application of micronized crospovidone of low bulk density. The formulation has been developed in the laboratory for two different drugs, so that it can be regarded as a typical guide formulation. It contains citric acid, to adjust the pH to 4.9, to optimize the chemical stability of the drug, ampicillin trihydrate or amoxicillin trihydrate. [Pg.170]

The optimum quantity of 6% crospovidone in the formulation in Table 143 was determined from the relative sediment volume. Figure 86 shows that, at this concentration, no further sedimentation takes place after 24 hours. With lower quantities of micronized crospovidone, a sediment was clearly visible. [Pg.170]

The laboratory formulation in Table 144 provides an example of the use in acetaminophen instant granules, e.g. for children [296]. In this formulation, micronized crospovidone has two additional functions it masks the bitter taste of acetaminophen almost completely, and it guarantees the release of the active sub-... [Pg.170]

Table 143. Antibiotic dry syrup with micronized crospovidone for children [615]... Table 143. Antibiotic dry syrup with micronized crospovidone for children [615]...
In an azithromycin dry syrup micronized crospovidone not only stabilizes the suspension physically but also maskes the bitter taste of the drug substance [615]. The formulation given in Table 145 was also developed on a laboratory scale and demonstrates the use of micronized crospovidone in an antiacid dry syrup from which a suspension is prepared as the administration form. [Pg.172]

Again, the quantity of micronized crospovidone was determined from the relative sediment volume. As is evident from Fig. 87, no sedimentation was observed above a crospovidone concentration of 9% in the final suspension (= 29 g crospovidone in the sales product). After several weeks, it was still very easy to redisperse the suspension with a few rocking movements. [Pg.172]

As early as 1968, a patent was granted for the use of insoluble polyvinyl pyrroli-done as an active substance for treating certain stomach and intestinal disorders [125]. Pharmaceutical products containing micronized crospovidone as an active substance have been sold in France since the 70s on the basis of the results in a series of publications [443-454]. They contain 2g of crospovidone per dose, which, in one case, is combined with karaya gum as a further active substance. The functions and medical indications listed in Table 146 are to be found in the clinical literature and with the pharmaceutical products. This application of micronized crospovidone is based on the local effect on the mucous membrane, as opposed to a systemic effect, as it is insoluble and therefore not absorbed. This is why practically no side-effects are listed. [Pg.174]

Table 147 gives a guide formulation developed in the laboratory for effervescent tablets for children, containing 1 g of micronized crospovidone as the active ingredient. No problems are to be expected with the chemical stability of this formulation. However, moisture-proof packaging is recommended, to stabilize the physical properties of the tablets for the duration of their intended shelf-life. [Pg.174]


See other pages where Micronized crospovidone is mentioned: [Pg.82]    [Pg.83]    [Pg.110]    [Pg.150]    [Pg.160]    [Pg.160]    [Pg.161]    [Pg.171]    [Pg.172]    [Pg.173]    [Pg.174]    [Pg.175]    [Pg.177]   
See also in sourсe #XX -- [ Pg.160 , Pg.161 , Pg.168 , Pg.169 , Pg.170 , Pg.171 , Pg.172 , Pg.173 , Pg.175 , Pg.176 , Pg.178 ]




SEARCH



Crospovidone

Micron

Micronization

Micronized

Micronized crospovidone as an active substance

Micronized crospovidone of low bulk density as a stabilizer for oral and topical suspensions

Micronizer

Micronizing

© 2024 chempedia.info