Micronized crospovidone as an active substance

As early as 1968, a patent was granted for the use of insoluble polyvinyl pyrroli-done as an active substance for treating certain stomach and intestinal disorders [125]. Pharmaceutical products containing micronized crospovidone as an active substance have been sold in France since the 70s on the basis of the results in a series of publications [443-454]. They contain 2g of crospovidone per dose, which, in one case, is combined with karaya gum as a further active substance. The functions and medical indications listed in Table 146 are to be found in the clinical literature and with the pharmaceutical products. This application of micronized crospovidone is based on the local effect on the mucous membrane, as opposed to a systemic effect, as it is insoluble and therefore not absorbed. This is why practically no side-effects are listed. 

The preferred dosage forms are instant drink tablets for suspension in a glass of water, instant granules, and ready suspensions. These dosage forms make it possible both for adults and children to take the large quantity of active substance without problems. 

In another formulation for a water-dispersible tablet based on 74% crospovidone, containing as auxiliaries, microcrystalline cellulose, corn starch, silicon dioxide, talc etc. [615], it was possible to confirm that the compression force and 

Granulate mixture I with solution II, pass through a 0.8-mm sieve, dry, mix with III and  

Dissolve sorbitol, povidone K 90, the preservatives and flavours in water, add crospovido- 

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