Instant granules

Hellen L, Yliruusi J, Merkku P, Kristoffersson E. Process variables of instant granulator and spheroniser I. Physical properties of granules, extrudate and pellets. Int J Pharm 1993 96 197-204. 

Hellen L, Yliruusi J. Process variables of instant granulator and spheroniser III. Shape and shape distributions of pellets. Int J Pharm 1993 96 217-223. Chapman SR, Rowe RC, Newton JM. Characterization of the sphericity of particles by the one plane critical stability. J Pharm Pharmacol 1988 40 503-505. Rowe RC, Sadeghnejad GR. The rheology of mcc powder/water mixes-measurement using a mixer torque rheometer. Int J Pharm 1987 38 227-229. O Connor RE, Schwartz JB. Spheronization II Drug release from drug-diluent mixtures. Drug Dev Ind Pharm 1985 11 (9-10) 1837-1857. 

Vitamin B Complex + Vitamin C Instant Granules (2 RDA of Vitamins) 5. Chemical stability of the granules (20-25 °C)... 

In this book, a number of formulations for made-up suspensions or extemporaneous suspensions produced from instant granules or dry syrups... 

Suspension stabilizer Suspensions, instant granules, dry syrups... 

The drugs most frequently incorporated in instant granules are antacids and vitamins. Table 75 gives details of a magaldrate instant granule formulation developed in the laboratory, as an example of this dosage form. 

Further examples of formulations for instant granules are described in Chapter 3, under Section 3.4.4.3. 

Various auxiliaries with different functions are used in suspensions or dry syrups and instant granules for the preparation of suspensions. These include thickeners, hydrophilic polymers as dispersing agents, sugars, surfactants, electrolytes, colorants,etc. [296]. 

Further examples of laboratory formulations for dry syrups, instant granules and suspensions are given in Section 3.4.4.3. 

The effect of low-density micronized crospovidone (e.g. Kollidon CL-M) in stabilizing suspensions can also be partly explained in terms of Stokes law Its particle size is very fine (see Section 3.2.2), its bulk density low and its density in water also low as a result of swelling. The product differs in these properties from the coarser products and other micronized types which have a higher bulk density with a similar swelling volume, and make it useful as an auxiliary for oral and topical suspensions for reducing sedimentation and improving redispersibility [98]. The same applies, whether the commercial product is a suspension or a dry syrup, or instant granules from which the patient prepares an oral suspension. 

Dry syrups and instant granules are more important these days than finished suspensions, as the active ingredient is more stable in these dry products, and the physical stability requirements of the suspension, as the actual administration form, are not so critical. Because of their stability, dry syrups are often used as the dosage form for antibiotics. Instant granules are widely used for antacids,because of the possibility of microbial contamination with finished suspensions, for vitamins (plus minerals) for stability reasons, and for analgesics. 

The laboratory formulation in Table 144 provides an example of the use in acetaminophen instant granules, e.g. for children [296]. In this formulation, micronized crospovidone has two additional functions it masks the bitter taste of acetaminophen almost completely, and it guarantees the release of the active sub-... 

The preferred dosage forms are instant drink tablets for suspension in a glass of water, instant granules, and ready suspensions. These dosage forms make it possible both for adults and children to take the large quantity of active substance without problems. 

Aceclofenac Gel-Cream (1.5%) Aceclofenac Instant Granules (1.3%) Acetaminophen see Paracetamol Acetylsalicylic Acid + Paracetamol... 

Veterinary Application Multivitamin Instant Granules Multivitamin Oral Gel (vet.)... 

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