Silicified microcrystalline cellulose

Silicified microcrystalline cellulose is used as a filler in the formulation of capsules and tablets. It has improved compaction properties in both wet granulation and direct compression compared to conventional microcrystalline cellulose. " Silicified microcrystalline cellulose was specifically developed to address the loss of compaction that occurs with microcrystalline cellulose after wet granulation. 

The effects of tablet binders, such as polyethylene glycols, microcrystalline cellulose, silicified microcrystalline cellulose, pregelatinized starch, and povidone, on the physical and mechanical properties of sodium bicarbonate tablets have also been investigated. ... 

Guo M, Augsburger LL. Potential application of silicified microcrystalline cellulose in direct-fill formulations for automatic capsule-filling machines. Pharm Dev Technol 2003 8(l) 47-59. 

The essential difference between physical and chemical interactions is that in the former the interacting molecules are not chemically modified in any way. Hydrogen bonding may change, but there are no chemical changes that create a different molecule. However, this does not mean that the different components of the interaction can be easily separated the resultant mixture may be so intimate that separation is not possible. For example, silicified microcrystalline cellulose after processing cannot be separated entirely into its two separate components (fumed silica and microcrystalline cellulose). But on examination, using a number of vibrational spectroscopic methods, it was shown to be an intimate physical mixture and not a new chemical entity (8). 

Tobyn MJ, McCarthy GP, Staniforth JN, Edge S. Physicochemical comparison between microcrystalline cellulose and silicified microcrystalline cellulose. Int J Pharm 1998 169 183-194. 

Sherwood BE, Becker JW. A new class of high functionality excipients silicified microcrystalline cellulose. Pharm Tech 1998 22(10) 78—88. 

Steele DF, Edge S, Tobyn MJ, Moreton RC, Staniforth JN. Adsorption of an amine drug onto microcrystalline cellulose and silicified microcrystalline cellulose samples. Drug Dev Ind Pharm 2003 29(4) 475 487,... 

Moreton RC. Cellulose, silicified microcrystalline. In Kibbe AH ed. Handbook of Pharmaceutical Excipients. Washington, D.C. American Pharmaceutical Association and London Pharmaceutical Press, 2000 110-111. 

Prosolv SMCC —silicified microcrystalline cellulose consisting of microcrystalline cellulose and colloidal silicon dioxide. 

Kachrimanis, K., Nikolakakis, I., and Malamataris, S. (2003), Tensile strength and disintegration of tableted silicified microcrystalline cellulose Influences of interparticle bonding,/. Pharm. Sci., 92(7), 1489-1501. 

Cellulose, microcrystalline silicified Combination of microcrystalline cellulose and silica (Prosolv )... 

Cellulose, silicified microcrystalline Inorganic materials Prosolv Penwest... 

Silicified microcrystalline cellulose is a coprocessed mixture of microcrystalline cellulose and 2% colloidal silicon dioxide, which has improved flow and binding properties compared to microcrystalline cellulose itself. ... 

Sherwood, B.E. Hunter, E.A. Staniforth, J.N. Silicified microcrystalline cellulose (SMCC ). A new class of high functionality binders for direct compression diluents. 43. Pharm. Res. 1996,13 (9), S197. 

Microcrystalline cellulose and carrageenan microcrystalline cellulose and carboxymethylcellulose sodium microcrystalline cellulose and guar gum powdered cellulose silicified microcrystalline cellulose. 

Silicified microcrystalline cellulose is a synergistic, intimate physical mixture of two components microcrystalline cellulose and colloidal silicon dioxide (for further information see Cellulose, Microcrystalline and Colloidal Silicon Dioxide). Silicified microcrystalline cellulose contains 2% w/w colloidal silicon dioxide. 

Excipient Silicified microcrystalline cellulose Manufacturer JRS Pharma LP Lot No. CSD5866 Magnification lOOx... 

Silicified microcrystalline cellulose is stable when stored in a well-closed container in a cool, dry place. 

The colloidal silicon dioxide appears physically bound onto the surface and inside the silicified microcrystalline cellulose particles. Extensive studies using different spectroscopic methods have failed to show any form of chemical inter-action.<" ")... 

Observe normal precautions appropriate to the circumstances and quantity of material handled. Handling of silicified microcrystalline cellulose can generate nuisance dusts and the use of a respirator or dust mask may be necessary. 

Since the colloidal silicon dioxide is physically bound to the microcrystalline cellulose the general recommendations of gloves, eye protection, and a dust mask should be followed when handling silicified microcrystalline cellulose. 

Silicified microcrystalline cellulose is a physical mixture of two materials both of which are generally regarded as nontoxic Microcrystalline cellulose GRAS listed. Included in the FDA Inactive Ingredients Guide (inhalations, oral capsules, powders, suspensions, syrups, and tablets). Included in nonparenteral medicines licensed in Europe and the US. Included in the Canadian List of Acceptable Non-medicinal Ingredients. 

Silicified microcrystalline cellulose has greater tensile strength and requires lower compression pressures than regular grades of microcrystalline cellulose. Furthermore, silicified microcrystalline cellulose maintains its compactability when wet granulated the compacts exhibit greater stiffness and they require considerably more energy for tensile failure to occur. 

Staniforth JN, Sherwood BE, Hunter EA. Towards a new class of high functionality tablet binders. II silicified microcrystalline cellulose (SMCC). Pharm Res 1996 13(9) S197. 

Habib SY, Abramowitz R, Jerzewski RL, et al. Is silicified wet-granulated microcrystalline cellulose better than original wet-granulated microcrystalline cellulose Pharm Dev Technol 1999 4(3) 431-437. 

Buckton G, Yoremochi E. Near IR spectroscopy to quantify the silica content and differences between silicified miicrocrystalline cellulose and physical mixtures of microcrystalline cellulose and silica. Int J Pharm 1998 169 183—194. 

Buckton G, Yoremochi E, Yoon NL, Moffat AC. Water sorption and near IR spectroscopy to study the differences between microcrystalline cellulose and silicified miicrocrystalline cellulose after wet granulation. Int J Pharm 1999 181 41 7. 

Luukkonen P. Newton JM, Podczcck F, ct al. Use of capillary rheometry to evaluate the rheological properties of microcrystalline and silicified microcrystalline cellulose. Int J Pharm 2001 216 147-57,... 

Luukkonen P, Schaefer T. Hellen L. et al. Rheological characterization of microcrystalline cellulose and silicified microcrystalline cellulose wet masses using a mixer torque rheometer. Im J Pharm 1999 188 181-92. 

Silicified microcrystalline cellulose—co-processed microcrystalline cellulose that has been silicified with colloidal silicon dioxide... 

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