Microcrystalline cellulose disintegrant properties

However, some excipients have multiple functions. For example, microcrystalline cellulose can function as a filler, a binder, and a disintegrant. As seen in Table 7.3, a typical low-dose formulation could include more than 85% filler—binders. Thus, physical and chemical properties for these specialty excipients are extremely important in a low-dose formulation for manufacturability, product performance, and longterm stability. Because the poor physicomechanical properties of components are not altered during manufacture as they are in the wet or dry granulation process, critical material properties and their impact on product quality attributes should be well characterized and understood.23 Discussion in this section will focus on fillers-binders. For those requiring more information on excipients, several excellent books and review articles are available in the literature.24-27... 

Microcrystalline cellulose is one of the most commonly used filler-binders in direct compression formulations because it provides good binding properties as a dry binder, excellent compactibility, and a high dilution potential. It also contributes good disintegration and lubrication characteristics to direct compression formulas. When compressed, microcrystalline cellulose undergoes plastic deformation. The acid hydrolysis portion of the production process introduces slip planes and dislocations into the material. Slip planes, dislocations, and the small size of the individual crystals aid in the plastic flow that takes place. The spray-dried particle itself, which has a higher porosity compared with the absolute porosity of cellulose, also deforms... 

Microcrystalline cellulose (MCC) is obtained by a controlled acid treatment intended to destroy the molecular bonding in the amorphous zones of cellulose. Usually HC1 or H2SO4 are used at 110°C for 15 min over native cellulose or regenerated cellulose. Colloidal gels are thus obtained showing thixotropy. MCC is used in the preparation of pharmaceutical compressed tablets due to its binding and disintegration properties. 

Microcrystalline cellulose - mainly used as a binder or diluent in solid oral dose formulations. It also has lubricant and disintegrant properties which make it a useful excipient in tablet manufacture. 

Microcrystalline cellulose Excellent compressibility, some disintegration properties available in different grades with specific applications... 

Cellulose, microcrystalline Good compression properties, may not need lubricant, can act as disintegrant (Avicel , Emcocel , Vivacel )... 

Microcrystalline cellulose is widely used in pharmaceuticals, primarily as a binder/diluent in oral tablet and capsule formulations where it is used in both wet-granulation and direct-compression processes.In addition to its use as a binder/diluent, microcrystalline cellulose also has some lubricant and disintegrant properties that make it useful in tableting. 

Free-flowing materials that do not disintegrate Dibasic calcium phosphate dihydrate Excellent flow properties. Very brittle material, and is best used in combination with microcrystalline cellulose or directly compressible starch. 

Tablets of 8 furosemid content were compressed with or without disintegrant using microcrystalline cellulose as binder. 2,5 CDP or 12,5 potato starch played the role of disintegrant. The properties of tablets are listed in Table IV.

The most often used diluent for capsules and powders is microcrystalline cellulose (Avicel PH 102 or Pharmacel 102, see also Sect. 23.4.1). Microcrystalline cellulose has both proper flow and disintegrating properties. However, microcrystalline cellulose has some drawbacks. For instance... 

Owing to the hydrophilic nature of chitosan, this compound has been used directly as compressible diluent in tablets. Chitosan has excellent properties as excipient for direct compression of tablets, where the addition of 50% chitosan results in rapid disintegration. The DD determines the extent of moisture absorption. Also, in immediate-release formulations, e.g., as a disintegrant in small amounts, where it has been found to have effects similar to or better than those of microcrystalline cellulose. Chitosan at concentrations higher than 5% is a better disintegrate than corn starch and microcrystalline cellulose, depending on chitosan crystallinity, DD, MW and particle size [61]. In addition, it has excellent tablet binder properties compared to other excipients [62]. 

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