Miconazole cream

Nystatin, clotrimazole, and miconazole creams or ointments applied two to four times daily with diaper changes have all shown to be effective in the treatment of candidal diaper rash. Although some of these products are available over the counter, parents and caregivers should be advised to initiate... 

Miconazole cream. Miconazole cream contains miconazole nitrate C18FL4CI4N2OHNCL 90-110% of prescribed or stated amount in a suitable basis. 

If miconazole cream is kept in aluminium tubes, their inner surfaces should be coated with a suitable lacquer. 

Assay of miconazole cream with calibration against an internal standard over a narrow concentration range... 

Metronidazole Tablet Cores (400 mg) Metronidazole Tablets (200 mg) Metronidazole Tablets (500 mg) Metronidazole Vaginal Gel (1.2%) Miconazole Cream (2%)... 

Based on this information the risk of a clinically relevant drug interaction with systemically administered drugs and these topical azoles would seem to be very small. However, for a case report of raised INR in a man taking warfarin while using miconazole cream for a groin infection, see Coumarins and related drugs + Azoles Miconazole , p.388. 

Devaraj A, O Beime JPO, Veasey R, DunkAA Interactionbetweenwai in and topical miconazole cream. BMJ (2002) 325,77. 

Miconazole If the drug (cream or tablet) is administered vaginally, insert the drug high in the vagina using tiie applicator provided with the product. 

Miconazole (Monistat) 2% cream, 5 g intravaginally for 7 days 100-mg vaginal suppository daily for 7 days ... 

Miconazole (Micatin, 2% cream—apply to affected areas First-line agent... 

Miconazole nitrate cream contains not less than 90% and not more than 110% of the labeled amount of miconazole nitrate (Ci8H14C14N2OHN03). 

Procedure Separately inject equal volumes (about 1 pL) of the Assay preparation and the Standard preparation into the chromatograph, record the chromatograms, and measure the peak responses. Calculate the quantity, in mg, of miconazole nitrate (C18H14CI4N2O HNO3) in the portion of cream given by the formula ... 

Internal standard solution, Standard preparation, and Chromatographic system Prepare as directed in the Assay under Miconazole nitrate cream. 

Massaccesi reported the development of a two-phase titration method for the analysis of miconazole and other imidazole derivatives in pure form and in pharmaceutical formulation [14], To the sample (10 mg) are added 10 mL of water, 10 mL of 1 M-sulfuric acid, 25 mL of dichloromethane and 1 mL of 0.05% indophenol blue (C.I. No. 49700) in dichloromethane solution and the solution is titrated with 10 mM sodium dodecyl sulfate until the color of the organic phase changes from blue to pale yellow. Results obtained for the drug in pure form, tablets, suppositories, cream and lotion agreed with the expected values and the coefficient of variation (n = 6) were 0.3-0.35%. Imidazole and the other constituents of the pharmaceutical preparations did not interfere. 

Bonazzi et al. [18] reported the determination of miconazole and other imidazole antimycotics in creams by supercritical fluid extraction and derivative ultraviolet spectroscopic method. Cream based pharmaceuticals were mixed with celite and anhydrous sodium sulfate and extracted by supercritical fluid extractor (SFE) with... 

Goger and Gokcen [19] developed a quantitative method for the determination of miconazole in cream formulations that contain benzoic acid as preservative by second order derivative spectrophotometry. The procedure was based on the linear relationship in the range 100—500 pg/mL between the drug concentration and the second-derivative amplitudes at 276 nm. Results of the recovery experiments performed on various amounts of benzoic acid and the determination of miconazole in cream confirmed the applicability of the method to complex formulations. 

Liu et al. [23] used a third-derivative spectrophotometric method for the determination of miconazole nitrate in Pikangshuang (cream). The detection range was 60-300 pg/mL and recovery was 100.1%. 

Wrobel et al. [29] described a simple method for the determination miconazole in pharmaceutical creams, based on extraction and second-derivative spectrophotometry. In the presence of sodium lauryl sulfate (0.5%) and sulfuric acid (0.4 mol/L), the miconazole and internal standard (methylene blue) were extracted to 100 pL of methylene chloride. The organic phase was evaporated in the nitrogen stream and the dry residue was dissolved in methanol (1.5 mL). The analytical signal was obtained as the ratio between second-derivative absorbances measured at 236.9 nm... 

Thomas et al. [31] used a colorimetric method for the estimation of miconazole nitrate in creams. The method is based on the ion-pair extraction with bromocresol purple solution and measurement of the solution at 410 nm. 

Van de Vaart et al. [45] used a thin-layer chromatographic method for the analysis of miconazole and other compounds in pharmaceutical creams. The drugs in creams were analyzed by thin-layer chromatography on silica gel plates with ether in pentane-saturated chamber or with butanol-water-acetic acid (20 5 2). Both active ingredients and vehicle components were detected and Rf values of 67 active ingredients are tabulated. Additional eluents may be needed to separate certain combinations of ingredients. 

Kublin and Kaniewska [52] used a gas chromatographic method for the determination of miconazole and other imidazole antimycotic substances. The conditions have been established for the quantitative determination of miconazole and the other drugs, which are present in pharmaceuticals such as ointments and creams. The column, packed with UCW-98 on Chromosorb WAW, and flame-ionization detector were used. The statistical data indicate satisfactory precision of the method, both in the determination of imidazole derivatives in substances and in preparation. 

Guo et al. [53] developed a gas chromatographic method for the analysis of miconazole nitrate in creams and injections. The conditions were flame ionization detector, stationary phase of 5% SE 30 support of Chromosorb W (AS-DMCS, 80—100 mesh) packed column 3 m x 3 mm column temperature 275 °C injection temperature 290 °C and diisooctyl sebacate and internal standard. The average recoveries for creams and injections were 97.7 and 101.4%, respectively. The relative standard deviations were 2.2 and 1.3%, respectively. 

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