Methysergide effects

However, the specific serotonin uptake inhibitor fluoxetine failed to produce an MBDB-like cue and failed to block the stimulus effects of MBDB when it was given prior to a training dose of MBDB. Table 3 summarizes results of fluoxetine testing in MBDB-trained rats. In other exploratory studies, pretreatment of MDMA-trained rats with either methysergide or ketanserin failed to block completely the MDMA-discriminative stimulus. 

FIGURE 2. Effects of d-amphetamine and methysergide on the cumulative frequency of attack hites and sideways threats (top) and walking duration (bottom) during the initial and later resident-intruder confrontations... 

Significantly dififerent from 0 methysergide dose, Newman-Keuls test following significant ANOVA main effect... 

Methysergide is an ergotamine derivative that impacts central serotonin balance.51 It is reserved for use in migraineurs refractory to other agents, due to its significant adverse-effect profile. As an ergot compound, it is a vasoconstrictor that may worsen vascular dilatory reserves and precipitate cardiovascular events or ischemic stroke in those with... 

Methysergide is best tolerated when taken with meals. Side effects other than GI intolerance are many and include insomnia, vivid dreams, hallucinations, claudication, and muscle cramps. The labeling should be consulted for additional side effects and contraindications. 

The catecholamine-releasing agent beta-phenylethylamine (PEA) also produces the 5-HT syndrome (156) by direct activation of 5-HT receptors. The 5-HT antagonists methysergide and mianserin blocked the syndrome-producing effects of PEA, while depletion of 5-HT by PCPA or 5,7-DHT treatments was not effective. A possible role of catecholamines in the syndrome-producing effects of PEA cannot presently be discounted. 

Herrman, W. M., Horowski, R., Dannehl, K., Kramer, U., and Lurati, K. (1977) Clinical effectiveness of lisuride hydrogen maleate A double-blind trial versus methysergide. Headache, 17 54-60. 

Recent smooth muscle constrictor studies performed in our laboratory in collaboration with Dr. Marion Buck at Yale University have yielded interesting results. Various fractions were first tested in human volunteers for bronchoconstrictor activity and then bioassayed by the rat stomach strip isolated organ bath technique. The fractions demonstrating constrictor activity in man correlated precisely with the constrictor activity in the isolated organ bath. This effect was antagonized by methysergide (6 ). 

Methysergide is a lysergic acid derivative with an antiserotonin and antivasoconstrictor effect. Dosage is 5 mg/d, reserved for refractory migraine. 

Type B effects are not related to the pharmacological properties of these drugs. Serious side effects may occur. Allergic skin and liver reactions to aspirin and paracetamol have been reported with risk of fibrosis, particularly in the retroperitoneal region for methysergide and hypersensitivity reactions with NSAID and pure analgesics. 

Jakala P, Sirvio J, Riekkinen P, et al Effects of p-chlorophenylalanine and methysergide on the performance of a working memory test. Pharmacol Biochem Behav 44 411-418, 1993... 

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