Methysergide

Lisuride dihydrogen maleate (h/Jj 30-35), methysergide maleate (h/ij 40-45), dihydroergotamine mesylate (hRf 45-50) and ergotamine tartrate (hRj 70-75) appeared as blue violet chromatogram zones on a yellow background. The detection limits — calculated for free base — were 3-4 ng substance per chromatogram zone. 

Fig. 2 Reflectance scan of a chromatogram track of 90 ng each lysuride hydrogen maleate (1), methysergide maleate (2), dihydroergotamine mesylate (3) and ergotamine tartrate (4) per chromatogram zone.

However, the specific serotonin uptake inhibitor fluoxetine failed to produce an MBDB-like cue and failed to block the stimulus effects of MBDB when it was given prior to a training dose of MBDB. Table 3 summarizes results of fluoxetine testing in MBDB-trained rats. In other exploratory studies, pretreatment of MDMA-trained rats with either methysergide or ketanserin failed to block completely the MDMA-discriminative stimulus. 

Gold, L.H., and Koob, G.F. Methysergide potentiates the hyperactivity produced by MDMA in rats. Pharmacol Biochem Behav 29 645-648. 

FIGURE 2. Effects of d-amphetamine and methysergide on the cumulative frequency of attack hites and sideways threats (top) and walking duration (bottom) during the initial and later resident-intruder confrontations... 

Significantly dififerent from 0 methysergide dose, Newman-Keuls test following significant ANOVA main effect... 

NOTE Following a habituation period, rats were injected with methysergide (0-10 mg/kg, SC C)... 

MDMA plus 25 mg/kg methysergide on locomotor activity in rats with 6-OHDA or sham lesions of the nucleus accumbens... 

QUESTION Have you had the opportunity to look at the impact of methysergide pretreatment on MDMA s effeets on exploration and rearing ... 

QUESTION Do you have any explanation for sensitization within the MDMA or the methysergide There has been evidence of serotonergic inhibition. 

Methysergide is an ergotamine derivative that impacts central serotonin balance.51 It is reserved for use in migraineurs refractory to other agents, due to its significant adverse-effect profile. As an ergot compound, it is a vasoconstrictor that may worsen vascular dilatory reserves and precipitate cardiovascular events or ischemic stroke in those with... 

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