Dihydroergotamine mesylate

Lisuride dihydrogen maleate (h/Jj 30-35), methysergide maleate (h/ij 40-45), dihydroergotamine mesylate (hRf 45-50) and ergotamine tartrate (hRj 70-75) appeared as blue violet chromatogram zones on a yellow background. The detection limits — calculated for free base — were 3-4 ng substance per chromatogram zone. 

Fig. 2 Reflectance scan of a chromatogram track of 90 ng each lysuride hydrogen maleate (1), methysergide maleate (2), dihydroergotamine mesylate (3) and ergotamine tartrate (4) per chromatogram zone.

Over the years it has been interesting to note that many compounded products eventually become commercially available products. Recent examples might include fentanyl lozenges, minoxidil topical solution, nystatin lozenges, clindamycin topical solution, tetracaine-adrenalin-cocaine (TAG) solution, dihydroergotamine mesylate nasal spray, buprenorphine nasal spray, buffered hypertonic saline solution, and erythromycin topical solution as well as numerous other dermatological and pediatric oral liquids and some... 

Absorption/Distributton - Gl and sublingual absorption of ergotamine is incomplete and erratic following oral administration, peak blood levels are reached in about 2 hours. Following intranasal administration, however, the mean bioavailability of dihydroergotamine mesylate is 32% relative to the injectable administration. 

Ergot alkaloids dihydroergotamine mesylate methysergide maleate... 

Dose. 1 to 3 mg of dihydroergotamine mesylate, repeated if necessary to a maximum of 10 mg daily. 

Lipton R. Ergotamine tartrate and dihydroergotamine mesylate Safety profiles. Headache 1997 37(suppl 1) S33 1. 

Migranal (Dihydroergotamine mesylate). Valeant Pharmaceuticals International. US Prescribing information, March 2006,... 

Fig 2 Reflectance scan of a chromatogram track with 90 ng of each substance per chromatogram zone 1 = lisuride dihydrogen maleate, 2 = methyseigide maleate, 3 = dihydroergotamine mesylate, 4 = ergotamine tartrate. 

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