Methysergide toxicity

Other toxic effects of the ergot alkaloids include drowsiness and, in the case of methysergide, occasional instances of central stimulation and hallucinations. In fact, methysergide was sometimes used as a substitute for LSD by members of the "drug culture."... 

ERGOT DERIVATIVES MACROLIDES, QUINU-PRISTIN/DALFOPRISTIN, t ergotamine/methysergide levels with risk of toxicity Inhibition of CYP3A4-mediated metabolism of the ergot derivatives Avoid co-administration... 

Drugs may produce serious pulmonary toxicity as part of a more generalized disorder. The pleural thickening, effusions, and flbrosis that occur as an extension of the retroperitoneal flbrotic reactions of methysergide and practolol or as part of a drug-induced lupus syndrome are the most common examples (Table 29-8). 

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