Methysergide Ergot alkaloids

PVD), renal/liver dysfunction, pregnancy, hypersensitivity to ergot alkaloids. Methysergide pulmonary disease. [Pg.40]

CNS effects Hallucinations resembling psychosis are common with LSD but less so with the other ergot alkaloids. Methysergide has occasionally been used as an LSD substitute by users of recreational drugs. ... [Pg.163]

Ergot alkaloids dihydroergotamine mesylate methysergide maleate... [Pg.618]

Other toxic effects of the ergot alkaloids include drowsiness and, in the case of methysergide, occasional instances of central stimulation and hallucinations. In fact, methysergide was sometimes used as a substitute for LSD by members of the "drug culture."... [Pg.366]

Methysergide is a semisynthetic ergot alkaloid that is a potent 5HT2 receptor antagonist. It appears to stabilize serotonergic neurotransmission in the trigeminovascular system to block the development of neurogenic inflammation. [Pg.611]

TRIPTANS ERGOT ALKALOIDS- ERGOTAMINE, METHYSERGIDE T risk of vasospasm Additive effect 1. Do not administer ergotamine and almotriptan, rizatriptan, sumatriptan or zolmitriptan within 6 hours of each other 2. Do not administer methy-sergide and almotriptan, rizatriptan, sumatriptan or zolmitriptan within 24 hours of each other 3. Do not administer an ergot derivative and eletriptan or frovatriptan within 24 hours of each other... [Pg.235]

VORICONAZOLE ERGOT ALKALOIDS -ERGOTAMINE t ergotamine/methysergide levels, with risk of toxicity Inhibition of metabolism of the ergot derivatives Avoid co-administration. If absolutely necessary, advise patients to discontinue treatment immediately if numbness and tingling of the extremities are felt... [Pg.574]

CIMETIDINE ERGOT ALKALOIDS t ergotamine/methysergide levels, with risk of toxicity Inhibition of metabolism via CYP3A4 Avoid co-administration... [Pg.647]

Clinically important, potentially hazardous interactions with alprazolam, aprepitant, astemizole, atorvastatin, benzodiazepines, carbamazepine, chlordiazepoxide, cilostazol, clonazepam, clorazepate, colchicine, conivaptan, cyclosporine, dabigatran, dasatinib, diazepam, digoxin, dihydroergotamine, disopyramide, ergot alkaloids, fesoterodine, fluoxetine, flurazepam, fluvastatin, HMG-CoA reductase inhibitors, imatinib, ixabepilone, lapatinib, lopinavir, lorazepam, lovastatin, methylprednisolone, methysergide, midazolam, nilotinib, oxazepam, paroxetine, pimozide, pravastatin, prednisone, quazepam, repaglinide, rimonabant, rivaroxaban, sertraline, silodosin, simvastatin, solifenacin, temazepam, temsirolimus, tolvaptan, trabectedin, triazolam, warfarin, zidovudine... [Pg.132]

Clinically important, potentially hazardous interactions with alprazolam, astemizole, atazanavir, chlordiazepoxide, clonazepam, clorazepate, conivaptan, dasatinib, delavirdine, diazepam, dihydroergotamine, ergot alkaloids, estazolam, fentanyl, fesoterodine, flurazepam, halazepam, ixabepilone, lapatinib, methysergide, midazolam, pimozide, quazepam, rifapentine, sildenafil, solifenacin, St John s wort, temsirolimus, triazolam, vardenafil... [Pg.298]

Clinically important, potentially hazardous interactions with alfentanil, alfuzosin, alprazolam, amiodarone, amprenavir, aprepitant, astemizole, atazanavir, bepridil, buprenorphine, bupropion, carbamazepine, chlordiazepoxide, ciclesonide, clozapine, conivaptan, cyclosporine, cyproterone, dasatinib, diazepam, dihydroergotamine, ergot alkaloids, estazolam, eszopidone, etravirine, ezetimibe, fentanyl, fesoterodine, flecainide, flurazepam, fluticasone, halazepam, ivabradine, ixabepilone, ketoconazole, lapatinib, levothyroxine, meperidine, meptazinol, methysergide, midazolam, nifedipine, nilotinib, oral contraceptives, phenytoin, pimozide, piroxicam, propafenone, propoxyphene, quazepam, quinidine, ranolazine, rifabutin, rifampin, rifapentine, rimonabant, rivaroxaban, saquinavir, sildenafil, silodosin, simvastatin, solifenacin, St John s wort, tadalafil, temsirolimus, trabectedin, triazolam, vardenafil, voriconazole, zolpidem... [Pg.509]

Clinically important, potentially hazardous interactions with aprepitant, astemizole, carbamazepine, colchicine, cyclosporine, dihydroergotamine, ergot alkaloids, ergotamine, erythromycin, fluoxetine, fluvoxamine, methylprednisolone, methysergide, oral contraceptives, paroxetine, pimozide, prednisolone, rifampicin, sertraline, solifenacin, terfenadine, warfarin... [Pg.598]

The multiple pharmacological effects of ergot alkaloids complicate determination of their precise mechanism of action in the acute treatment of migraine. Actions of ergot alkaloids at 5-HTj jj receptors likely mediate their acute antimigraine effects. The ergot derivative methysergide. [Pg.197]

Maulding HV and Zoglio MA, Physical chemistry of ergot alkaloids and derivatives. I. Ionization ccHistants of several medicinally active bases, /. Pharm. Sci, 59, 700-701 (1970). NB See Dihydroergocomine and methysergide for details. [Pg.178]

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