Methylamine solubility

Monomeihylamine, methylamine, CH3NH2-Colourless, inflammable gas with an ammo-niacal odour, very soluble in water, m.p. 

Caution.—If the ethanol used to extract the methylamine hydrochloride is not absolute, i.e., if it contains traces of water, considerably less than the above suggested quantity will be required for the extraction, because the solubility of the hydrochloride will be markedly increased by the water present. The recrystallised material will now, however, contain traces of ammonium chloride. 

The absence of ammonium chloride and methylamine hydrochloride may be shown by the complete solubility of the product in chloroform. 

Footnote 4 - The solubility of Ammonium Chloride in absolute Ethanol is 0.6g/100g at 15C. The solubility in n-Butyl Alcohol is neglible, even at its boiling point. If you use n-Butyl Alcohol, you will only need to perform 3 reflux/filter operations to obtain sufficiently pure Methylamine Hydrochloride. 

Isoprene [78-79-5] (2-methyl-1,3-butadiene) is a colorless, volatile Hquid that is soluble in most hydrocarbons but is practically insoluble in water. Isoprene forms binary azeotropes with water, methanol, methylamine, acetonitrile, methyl formate, bromoethane, ethyl alcohol, methyl sulfide, acetone, propylene oxide, ethyl formate, isopropyl nitrate, methyla1 (dimethoxymethane), ethyl ether, and / -pentane. Ternary azeotropes form with water—acetone, water—acetonitrile, and methyl formate—ethyl bromide (8). Typical properties of isoprene are Hsted in Table 1. 

Other preparative routes iaclude hydrogenation of succinonitdle in the presence of methylamine and hydrogenation of solutions of maleic or succinic acid and methylamine (82,83). Properties are Hsted in Table 3. l-Meth5i-2-pyrrohdinone is completely miscible with water, lower alcohols, lower ketones, ether, ethyl acetate, chloroform, and benzene. It is moderately soluble in aUphatic hydrocarbons and dissolves many organic and inorganic compounds. 

Ninety-eight grams of 6-chloro-2-chloromethyl-4-phenylquinazoline 3-oxide hydrochloride were introduced into 600 cc of ice cold 25% methanolic methylamine. The mixture was initially cooled to about 30°C and then stirred at room temperature. After 15 hours the reaction product which precipitated was filtered off. The mother liquor was concentrated in vacuo to dryness. The residue was dissolved in methylene chloride, washed with water and dried with sodium sulfate. The methylene chloride solution was concentrated in vacuo and the crystalline residue was boiled with a small amount of acetone to dissolve the more soluble impurities. The mixture was then cooled at 5°C for 10 hours and filtered. The crystalline product, 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine 4-oxide, was recrystallized from ethanol forming light yellow plates, MP 236° to 236.5°C. 

Methylamine (CH3NH2) is a gas at room temperature and very soluble in water. An aqueous solution of methylamine has Kb = 4.2 X 10-4. How many liters of methylamine at 27°C and a pressure of 1.2 atm should be bubbled into 0.750 Lofa solution that is 0.588 M in the methylammonium ion (CH3NH3+) so that a buffer of pH 9.80 is obtained Assume no volume changes after methylamine is bubbled into the solution and ignore the vapor pressure of water. 

As already reported in Table 6, the solubility of phosphazene polymers is strongly influenced by the nature of the substituent groups attached at the phosphorus atoms along the -P=N- skeleton. Water-solubility, for instance, can be induced in polyphosphazenes by using strongly polar substituents (e.g. methylamine [84], glucosyl [495], glyceryl [496], polyoxyethylene mono-methylether [273] or sulfonic acid [497,498] derivatives), or may be promoted by acids or bases when basic (amino substituents like ethylamine [499]) or acid (e.g. aryloxy carboxylate [499] or aryloxy hydroxylate [295]) substituents are exploited. 

Radke et al. [28] described an automated medium-pressure liquid chromatograph, now commonly called the Kohnen-Willsch instrument. At present, the method is widely used to isolate different fractions of soluble organic matter (for instance, as described in Reference 29 to Reference 31). A combination of normal phase and reversed-phase liquid chromatography has been used by Garrigues et al. [32] to discriminate between different aromatic ring systems and degrees of methylamine in order to characterize thermal maturity of organic matter. 

Oxime carbamates have high polarity and solubility in water and are relatively chemically and thermally unstable. They are relatively stable in weakly acidic to neutral media (pH 4-6) but unstable in strongly acidic and basic media. Rapid hydrolysis occurs in strongly basic aqueous solutions (pH > 9) to form the parent oxime/alcohol and methylamine, which is enhanced at elevated temperature. Additionally, oxime carbamates are, generally, stable in most organic solvents and readily soluble in acetone, methanol, acetonitrile, and ethyl acetate, with the exception of aliphatic hydrocarbons. Furthermore, most oxime carbamates contain an active -alkyl (methyl) moiety that can be easily oxidized to form the corresponding sulfoxide or sulfone metabolites. 

Figure 4. shows the route from the high boiling residue of the direct synthesis to silicon carbo-nitride fibers. Methylchlorodisilanes and trichlorosilanes as additives are mixed in a specific ratio and react with methylamine and a small amount of ammonia to form an aminodisilane/oligosilazane. The subsequent polycondensation reaction of this mixture by heating to 250 °C yields a soluble and melt spinnable polysilazane. In comparision with the polysilane the properties of the polysilazane depend on the ratios of the disilanes/silanes and methylamine/ammonia and also on the reaction conditions. 

Using a model system of H-STXOL/PNPCF/ C-methylamine we have found that we can reliably obtain a good yield of the STXOL/amine product if STXOL solubility and solvent purity are carefully controlled. However, the same reaction conditions generally fail to produce a useful [STXOL]n-protein (n<2) preparation. 

Evidently the non-aqueous phase may possess acidic or basic characters either in virtue of its own properties, e.g. nitrobenzene and aniline, or through the addition of small quantities of soluble acidic or basic substances, e.g. salicylic acid to salicylaldehyde or methylamine to nitrobenzene. 

A similar approach was taken for the synthesis of 45 by Miyaura. " Shaughnessy and Booth synthesized the water-soluble alkylphosphine 46, and found it to provide very active palladium catalysts for the reaction of aryl bromides or chlorides with boronic acids. The more sterically demanding ligand 47 was shown to promote the reactions of aryl chlorides with better results than 46. Najera and co-workers recently reported on the synthesis of di(2-pyridyl)-methylamine-palladium dichloride complexes 48a and 48b, and their use in the coupling of a variety of electrophiles (aryl bromides or chlorides, allyl chlorides, acetates or carbonates) with alkyl- or arylboronic acids very low catalyst loadings at Palladium-oxime catalysts 8a and 8b) have also been developed. In conjunction with... 

Since ammonium chloride is not absolutely insoluble in 100 per cent ethyl alcohol (100 g. dissolve 0.6 g. at 150) the methylamine hydrochloride purified in the manner described contains appreciable traces of it. A purer product can be prepared by recrystallizing from -butyl alcohol, in which the solubility of ammonium chloride even at the boiling temperature is negligibly small. Methylamine hydrochloride is somewhat less soluble in this solvent than in ethyl alcohol, but as a rule three extractions carried out at 90-100° with 4-6 parts of fresh butyl alcohol for each extraction result in a substantially complete separation. Since the last traces of the solvent are not readily removed by exposure to air, a solution of the recrystallized material in a small quantity of water should be distilled until free of alcohol, and allowed to crystallize. 

Ammonium nitrate slurries can be either prepared in the factory and loaded into cartridges or mixed on site and pumped down the shot-holes. Ammonium nitrate slurries consist of a saturated aqueous solution of ammonium (about 65%) and other nitrates (i.e. methylamine nitrate MAN ). This solution also contains additional amounts of undissolved nitrates together with a fuel. The fuel is generally aluminium powder but water-soluble fuels such as glycol may also be employed. The slurries can be made more sensitive by adding either TNT, PETN,... 

Bis(2-chloroethyl)methylamine hydrochloride is a white solid that is soluble in alcohols and very hygroscopic. It is a vesicant and requires careful handling with the use of gloves. 

Sodium and lithium are the most common metals, and diethyl ether, tetrahydro-furan, and HMPA are often used as cosolvents to overcome solubility problems. The Benkeser method,37 204 employing lithium in low-molecular-weight amines (methylamine, ethylamine, ethylenediamine), is a more powerful reducing agent... 

The complete solubility of the product in chloroform 1 shows the trimethylamine hydrochloride to be free from ammonium chloride and methylamine hydrochloride and the fact that no precipitate is obtained when tested with sodium hydroxide and benzene sulfonyl chloride in aqueous solution shows that dimethylamine hydrochloride is absent. 

Consider the structure of the methylamine, H2N—CH3, and predict if it is water-soluble. 

The first observation of the NMR spectrum of Na- in a metal solution without added cation-complexing agents has recently been reported (65a). The rationale behind this observation was that the solvent HMPA by itself appeared to fulfill many of the requirements generally sought from macrocyclic complexing agents high solubility via cation complexation, stability to electron reduction, weak anion solvation, etc. The NMR spectrum of Na- in fluid Na-HMPA solutions, shown in Fig. 26, exhibits precisely the same chemical shift as that observed for Na-in solutions of Na in anhydrous methylamine and ethylamine in the presence of 2,2,2-cryptand. The metal anion here is truly "gas-like in... 

Hexaphenols 47-49 are water-soluble at pH > 12. On alkylation with methyl bromacetate they were converted to hexaesters 50-52, followed by hydrolysis to yield hexaacids 53-55. These hexaacids are soluble in water at pH > 5 (less than 6 equivalent amounts of base added). Alternatively [20], on reaction with methylamine, followed by reduction of the intermediate hexaamide, hexaester 51 was converted to the corresponding hexaamine 56. The latter is soluble in mildly acidic water. 

Reduction ofarenes. Calcium in combination with amines, generally methylamine or ethylenediamine, reduces aromatic hydrocarbons to monoenes in generally high yield. Addition of t-butyl alcohol to this system effects reduction to nonconjugated dienes (Birch-type products). Ethylenediamine is essential in this case addition of a second amine is generally desirable for solubility reasons. ... 

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