Methyl methylphosphonofluoridate

The primary hydrolysis product of GD is pinacolyl methylphosphonic acid (PMPA). Other hydrolysis products include the breakdown of PMPA to MPA and pinacolyl alcohol. Major impurities found in GD consist of dipinacolyl methylphosphonate, methyl pinacolyl methylphosphonate, methyl methylphosphonofluoridate and methyl methacrylate. Toxicological data for MPA was discussed earlier in Section 2.2 and can be found in Table 2.4. There are no current toxicity data available on the major degradation product PMPA, although it is structurally similar to IMPA, which exhibits low toxicity (Tables 2.4 and 2.5). Toxicity reports have found that methyl methacrylate is considered to possess moderately acute effects and is irritating to the eyes... 

Diisopropyl methylphosphonate is an organophosphate compound that was first produced in the United States as a by-product of the manufacture of the nerve gas isopropyl methylphosphonofluoridate (GB, or Sarin) (ATSDR 1996 EPA 1989 Robson 1977, 1981). It is not a nerve gas and is not a metabolite or degradation product (Roberts et al. 1995). Diisopropyl methylphosphonate constitutes approximately 2-3% of the crude GB product, but it is neither a metabolite nor a degradation product of GB (EPA 1989 Rosenblatt et al. 1975b). Diisopropyl methylphosphonate is not normally produced except for its use in research. One method of producing diisopropyl methylphosphonate is to combine triisopropyl phosphite and methyl iodide. The mixture is then boiled, refluxed, and distilled, yielding diisopropyl methylphosphonate and isopropyl iodide (Ford-Moore and Perry 1951). Diisopropyl methylphosphonate may also be prepared from sodium isopropyl methylphosphonate by a reaction at 270° C, but a portion of the resulting diisopropyl methylphosphonate is converted to trimethylphosphine oxide at this temperature (EPA 1989). 

Methylphosphonic acid (MPA), a degradation product of gas chemical warfare agents, such as sarin (isopropyl methylphosphonofluoridate), soman or VX (0-ethy I -.S -2-di isopropyl am i noethvl methyl phosphonoth ioate), has been recognized selectively by an MIP chemosensor using potentiometric transduction (Table 6) [181]. The MIP preparation involved co-adsorption, in ethanol, of the methylphosphonic acid (MPA) template and octadecyltrichlorosilane, followed by silanization on the indium-tin oxide (ITO) electrode surface in the chloroform-carbon tetrachloride solution at 0 °C. Subsequently, the electrode was rinsed with chloroform to remove the template. A potential shift due to the presence of MPA was significant as compared to that due to interferants like methyl parathion, dimethoate, phosdrin, malathion, etc. The linear concentration range varied from 50 pM to 0.62 M MPA at LOD as low as 50 pM and an appreciably short response time of 50 s. 

Methyl-2-pentyl methylphosphonofluoridate Dimethyl ethylphosphonate Butyl ethylphosphonofluoridate 6163-76-3 18358-34-4 1067.2 1210.0... 

METHYL PHOSPHONIC DICHLORIDE see MOB399 METHYLPHOSPHONOFLUORIDIC ACID ISOPROPYL ESTER see IPXOOO METHYLPHOSPHONOFLUORIDIC ACID-1-METHYLETHYL ESTER see IPXOOO METHYLPHOSPHONOTHIOIC ACID-S-(2-(BIS(METHYLETHYL)AAaNO)ETHYL)o-ETHYL ESTER see EIGOOO... 

Synonyms Cyclosarin Cyclohexyl methylphos-phonofluoridate CMPF Cyclosin Methyl-phosphonofluoridic acid cyclohexyl ester Methyl cyclohexylfluorophosphonate Cyclohexyl ester of methylphosphonofluoridic acid Cyclo-hexylmethyl-fluorophosphonate Methylfluoro-cyclohexylphosphonate Nerve gas Nerve agent Chemical/Pharmaceutical/Other Class GF is a colorless, liquid, organophosphate human-made nerve agent with intermediate persistence. The evaporation rate is l/20th that of water. It has a... 

Nerve agents Also known as anticholinesterase agents, are chemical compounds that inhibit the ability of cholinesterase to hydrolyze acetylcholine, which is essential to mediation of neurotransmitter function in nerve impulses. Nerve agents include VX (0-ethyl S-(2-dusopropylaminoethyl) methylphospho-nothioate) and the G-series agents tabun (GA)-dimethylphosphoramido-cyanidate, sarin G -isopropyl methylphosphonofluoridate and soman (GD)-Pinacolyl methyl phosphonofluoridate. 

Other names for this agent include (1) O-pinacolyl methylphosphonofluoridate, (2) pinacolyl methylphosphonofluoridate, (3) EA1210, (4) methyl pinacolyl phosphonofluoridate, (5) methyl pinacolyloxy phosphoryl fluoride, (6) T-300, and (7) PMFP. It carries CAS 96-64-0. Thickened soman (TGD) (aka VR-55) is created by adding thickener to GD. 

A series of methylphosphonofluoridous esters has been synthesized recently using either the low-temperature reaction between methyl-difluorophosphine and the sodium alcoholate, or via antimony trifluoride fluorination of the corresponding chloridous ester 185). Alkylphos-... 

Synonyms methylphosphonofluoridic acid isopropyl ester isopropytmethylphospho-nofluoridate isopropytmethylfluorophos-phonate isopropoxymethylphosphoryl fluoride fluoroisopropoxymethyl phosphine oxide isopropyl ester of methyl-fluorophosphoric acid GB... 

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