Pinacolyl-alcohol

Pinacolyl alcohol Specific uses not 464-07-3 identified Soman (GD) 1.79... 

This material can be reduced to pinacolyl alcohol (C01-C087), which is an intermediate for production of Soman (C01-A003). 

Pimelic ketone, c366 Pinacolone, d572 Pinacolyl alcohol, d571... 

It consists in the conversion of pinacolyl alcohol into tetramethyl-ethylene with elimination of water ... 

Landor and co-workers (46) found that a reagent formed by reacting LAH with 2 molar equivalents of (-)-menthol also failed to give optically active alcohol in the reduction of pinacolone. Only racemic pinacolyl alcohol was formed. 

Phosphorus trichloride, Aluminum chloride. Isopropyl chloride. Methylene chloride. Hydrochloric acid. Sodium fluoride. Isopropyl alcohol. Silica gel. Isopropyl ether, Toluene Phosphorus trichloride. Aluminum chloride, Isopropyl chloride, Methylene chloride, Hydrochloric acid, Hydrofluoric acid, Isopropyl alcohol, Silica gel, Isopropyl ether Phosphorus trichloride, Aluminum chloride, Methyl chloride, Methylene chloride, Hydrochloric acid. Sodium fluoride, Pinacolyl alcohol. Silica gel. Isopropyl ether. Toluene Phosphorus trichloride. Aluminum chloride. Methyl chloride. Methylene chloride. Hydrochloric acid. Hydrofluoric acid, Pinacolyl alcohol. Silica gel. Isopropyl ether Phosphorus trichloride. Aluminum chloride. Methyl chloride. Methylene chloride. Hydrochloric acid, Pinacolyl alcohol. Silica gel. Isopropyl ether. Toluene... 

Phosphorus trichloride. Aluminum chloride. Methyl chloride. Methylene chloride. Hydrochloric acid, Pinacolyl alcohol. Toluene, Pyridine, Calcium chloride... 

Pimelic acid, h8 Pinacol, d491 Pinacolone, d497 Pinacolyl alcohol, d496 3-Pinanol, i83... 

Retention Index pinacolyl alcohol is based on 6 measurements performed by the OPCW Laboratory), CAS registry No. [464-07-3], Schedule 2.B.14 ... 

Some participants had difficulty in the identification of the early eluting chemicals pinacolyl alcohol... 

Pinacolyl alcohol and chloropicrin are volatile, very stable in an aqueous environment, and easily extractable with an organic solvent. Exercise caution when evaporating the sample the early eluting chemicals easily evaporate in this process. 

Saturated branched Isopropyl, Isobutyl, sec-Butyl, tert-Butyl. Also use pina-colyl instead of 1,2,2-trimethylpropyl. However, pinacolyl alcohol should preferably be named 3,3-dimethyl-2-butanol. Unsaturated Vinyl, Allyl, Isopropenyl. 

Dimethyl-2-butanol (DMB, pinacolyl alcohol, CAS 464-07-3) was a spiking chemical in the water sample in the first official proficiency test. One laboratory missed it because of insufficient sample preparation the water sample was not extracted with dichloromethane, in which the chemical is soluble, but was merely evaporated and the residue... 

Alkyl/cycloalkyl alkylphosphonofluoridates are generally obtained from an organophosphorus precursor, typically an alkylphosphonic difluoride, and an alcohol. In 1992, over 300 aliphatic and cyclic alcohols were found to be commercially available as fine chemicals, of which inexpensive primary and secondary alcohols are considered suitable for chemical weapons production. By these criteria, approximately 70 alcohols remain of prime interest for the preparation of Schedule l.A.l chemicals. Only pinacolyl alcohol, the precursor of soman, is contained in the CWC Schedule... 

Siddan and Narayan also employed 7-AI2O3 and Th02 for the dehydration of a number of model alcohols and observed that if the basicity of the alumina was increased by Na -ion doping, 7-elimination was enhanced using both neopentyl and pinacolyl alcohol. It appeared that as the alumina became less acidic and more basic, there was a shift from El/E2-like behaviour to an ElcB-type mechanism, which manifested itself in a concerted 7-elimination (Scheme 10 for neopentyl alcohol A,B = acid, base sites respectively reproduced by permission from J. Catal, 1979, 59, 405). This tendency was also observed by use of erythrof f/ireo)-3-methylpentan-2-ol. 

Chugaev Reaction. The conversion of an alcohol to an olefin by the thermal decomposition of its xantliate ester is called the Chugaev reaction. The unique feature of the reaction is that alcohols which frequently undergo rearrangements by usual dehydration methods can be dehydrated with no change in the carbon skeleton. Thus pinacolyl alcohol (XXXIV) leads to terf-butylethylene (XXXV),22 and optically... 

The rotational spectra of the four CWA simulants are shown in Figure 2. The upper two panels show the rotational spectmm of pinacolone (PC) and pinacolyl alcohol (PCA), respectively and are precursors to the nerve agent soman. The rotational constants, distortion terms, and dipole moment components (determined by ab initio calculations ) have been reported elsewhere. The rotational constants and projection of the permanent dipole moment onto the inertial axes are reported in Table 1. 

Chemistry The synthesis of soman is similar to that of sarin. The major alteration is that pinacolyl alcohol replaces isopropanol. Soman hydrolyzes over a range of pHs, with pinacolyl methylpho-sphonate and fluoride ions being the initial products. Subsequent hydrolysis of pinacolyl methyl-phosphonate is similar to the aging process associated with GD poisoning (below) (Michel et al., 1967). 

Pinacolyl alcohol CfiHuO 464-07-3 Hydrolysis of pinacolyl methylphosphonic acid... 

Figure 1. Reaction of soman (GD) with acetylcholinesterase (AChE). (a) Soman and the active site of AChE shown together but not having undergone any reaction, (b) Soman combined with AChE to form an inhibitor-enzyme intermediate, (c) The leaving group (fluoride) has been lost, leaving a complex of soman with AChE. (d) The ester link in the phosphonylated AChE has been hydrolyzed, the enzyme has reactivated and an alkylphosphate has been formed, (e) The link between the large pinacolyl group and phosphorus has been cleaved with the formation of a stable monoalkylphosphonylated complex with AChE and pinacolyl alcohol. The process is known as ageing .

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