Phosphoryl fluoride

Reaction with phosphorus trichloride yields phosphorus trifluoride and with phosphoryl fluoride and sulfur trioxide, the product is phosphorus penta-fluoride ... 

N-Nitro-N-methyUiydroxy acetamidenitrate Neopentylene phosphoryl fluoridate, Neopentylene fluorophosphate... 

Neopentylene fluorophosphate, 21 Neopentylene fluorophosphonothioate, 21 Neopentylene phosphoryl fluoridate, 21 Neopentylene thiophosphoras fluoridate, 21 Nerve agent, 11-14, 21, 39-41, 59, 65-67, 71, 78,... 

N-Nitro N-methylhydroxy acetamidenitrate, 21 N-2-Nitroxyethyl nitramine, 19 NPF, 21,100,115,168,222. See also Neopentylene phosphoryl fluoridate, neopentylene fluorophosphate, neopentylene fluorophosphate... 

Phosphonate Diethyl 1-Fluoro-ethane ElOa. 482 (H > F) Phosphoryl Fluoridate Diisopropyl ElOa, 50 (Toxicity)... 

The simplest oxide fluoride of phosphorus is phosphoryl fluoride, POF3, which exists as a colorless gas (bp -39.7°C). It is generally prepared by fluorination of phosphoryl chloride with metallic fluorides... 

Phosphoryl fluoride reacts as a base and, with BF , AsF5, and SbF5, oxygen-bridged 1 1 adducts are produced (88, 89). In liquid sulfur dioxide POF3 is weakly basic and it was in such a medium that the first transition-metal complex of this oxide fluoride, [Mn(OPF j)4]2v[AsF6l2, was produced in 1979 via the intermediate Mn(S02)v 2 AsFe]2 (90). 

Tetraalkylstannanes and phosphorus pentafluoride are commercially available. Commercial phosphorus pentafluoride contains a small amount of phosphoryl fluoride, but its presence does not hinder the exchange reaction or cause any subsequent difficulties in workup of the products. It may be removed if desired, however, by carefully fractionating the commercial sample through —112° (CS2 slush) and —196° traps. The former trap will retain the phosphoryl fluoride, whereas the pentafluoride will pass this trap and collect at —196°. The vapor pressure of phosphorus pentafluoride at —96° (toluene slush) is 335 mm. Hg the purity of the sample may be checked by comparison of its vapor pressure against this value. 

A slight modification of the above description is necessary if this reaction is to be used for the synthesis of other alkylfluoro-phosphoranes (CH3CH2PF4, CH2=CHPF4, n-CH3CH2CH2PF4). Because all other tetraalkylstannanes are not transferable in a vacuum system at 25°, they can be syringed into the reaction bulb before attachment to the vacuum lines. Care to use dry samples and equipment must be observed, however, since the presence of even small amounts of water will lead to formation of phosphoryl fluoride and silicon tetrafluoride. 

SYNS BFP BFPO BIS(DIMETHYLAMIDO)-PHOSPHORYL FLUORIDE BIS(DIMETHYLAMINO)-FLUOROPHOSPHATE BISDIMETHYLAMINO-FLUOROPHOSPHINE OXIDE CR 409 DIFO DIMEFOX DMF ENT 19,109 FLUOPHOSPHORIC ACID DI(DIMETHYLAMIDE) FLUORURE de N,N,N, N -TETRAMETHYLE PHOSPHORO-DIAMIDE (FRENCH) ... 

The fluorination with phosphoryl fluoride is not successful. For other reactions see Table 60. 

The first nonpeptide, irreversible inactivators of serine proteinases were phosphoryl fluoride derivatives such as diisopropylphosphofluoridate (see Figure 2.7) [168]. It was shown that the phosphofluoridates stoichiometri-cally inactivate serine proteinases, by coupling with the active-site serine hydroxyl group. They have since been used as a diagnostic tool for the classification of serine proteinases. Similarily, both aryl and aralkyl sulphonyl fluorides were determined to be inactivators, forming a sulphonyl enzyme derivative at Ser-195 which is resistant to hydrolysis. 

Other names for this agent include (1) O-pinacolyl methylphosphonofluoridate, (2) pinacolyl methylphosphonofluoridate, (3) EA1210, (4) methyl pinacolyl phosphonofluoridate, (5) methyl pinacolyloxy phosphoryl fluoride, (6) T-300, and (7) PMFP. It carries CAS 96-64-0. Thickened soman (TGD) (aka VR-55) is created by adding thickener to GD. 

Larsson, L. 1958b. A kinetic study of the reaction of isopropoxy-methyl-phosphoryl fluoride (Sarin) with hydrogen peroxide. Acta Chemica Scandinavia, 12 723-730. 

The phosphoryl fluorides are a source of many inorganic and organic derivatives.16,17 The easy cleavage of a phosphorus-chlorine or phosphorus-bromine bond is responsible for the synthetic utility of the compounds. 

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