2- methoxy-2-phenylethyl phenyl

Methoxy-2-phenylethyl phenyl tellurium was oxidized to the dimethyl acetal of phenylacetaldehyde by one molar-equivalent of 3-chloroperoxybenzoic acid in methanol3. 

Ethyl-2,4-dihydroxyphenyl)-2-phenylethanone, 1427 2-Hydroxy-l-[2-hydroxy-4-(2-phenylethyl)phenyl]ethanone, 1380 1 -(2-Hydroxy-4-methoxy-3-metliylphenyl)-2-phenylethanone, 1427 l-(2-Hydroxy-4-methoxy-5-metliylphenyl)-2-phenylethanone, 1427 1 -(2-Hydroxy-4-methoxy-6-metliylphenyl)-2-phenylethanone, 1428 l-(2-Hydroxy-6-methoxy-3-metliylphenyl)-2-phenylethanone, 1428 l-(4-Hydroxy-2-methoxy-5-metliylphenyl)-2-phenylethanone, 1428 1 -(4-Hydroxy-2-methoxy-6-metliylplienyl)-2-phenylethanone, 1428 l-(2-Hydroxy-3-methylphenyl)-2-(2-methoxyphenyl)ethanone, 1479 l-(2-Hydroxy-3-methylphenyl)-2-(4-methoxyplienyl)ethanone, 1480 1 -(2-Hydroxy-5-methylphenyl)-2-(2-methoxyphenyl)ethanone, 1480 1 -(2-Hydroxy-5-methylphenyl)-2-(4-methoxyphenyl)etlianone, 1480 1 -(4-Hydroxy-3-methylphenyl)-2-(4-methoxyphenyl)etlianone, 1480... 

Hydroxy[ 1,1 -biphenyl]-3-yl)-2,2-dimethyl- 1-propanone, 2097 l-[2-Hydroxy-5-(phenylethyl)phenyl]-l-propanone, 1941 1 -(4-Methoxy[ 1,1 -biphenyl]-3-yl)-2-methyl-1 -propanone, 2052 l-[4-Methoxy-3-(phenylinethyl)phenyl]-l-propanone, 1941... 

No stereoselectivity was observed in the formation of a 1 1 diastereomeric mixture of 2-hydroxy-2-phenylethyl p-tolyl sulfoxide 145 from treatment of (R)-methyl p-tolyl sulfoxide 144 with lithium diethylamide . However, a considerable stereoselectivity was observed in the reaction of this carbanion with unsymmetrical, especially aromatic, ketones The carbanion derived from (R)-144 was found to add to N-benzylideneaniline stereoselectivity, affording only one diastereomer, i.e. (Rs,SJ-( + )-iV-phenyl-2-amino-2-phenyl p-tolyl sulfoxide, which upon treatment with Raney Ni afforded the corresponding optically pure amine . The reaction of the lithio-derivative of (-t-)-(S)-p-tolyl p-tolylthiomethyl sulfoxide 146 with benzaldehyde gave a mixture of 3 out of 4 possible isomers, i.e. (IS, 2S, 3R)-, (IS, 2R, 3R)- and (IS, 2S, 3S)-147 in a ratio of 55 30 15. Methylation of the diastereomeric mixture, reduction of the sulfinyl group and further hydrolysis gave (—)-(R)-2-methoxy-2-phenylacetaldehyde 148 in 70% e.e. This addition is considered to proceed through a six-membered cyclic transition state, formed by chelation with lithium, as shown below . ... 

Diethyl (R)-(-)-[1 -((N-(R)-(1 -phenyl-2-methoxyethyl)amino)-3-methylbutyl)]-phosphonate Phosphonic acid, [1-(2-methoxy-1-phenylethyl)amino]-3-methylbutyl]-, diethyl ester, [R-(R, R )]- (159117-09-6), 75, 20... 

Benzo[6]furan is cleaved on reduction with excess sodium in liquid ammonia, followed by quenching with ammonium chloride or methanol, to produce 2-ethylphenol (69%). 2-Methyl- and 2-phenyl-benzo[6]furan similarly yield 2-propylphenol (54%) and 2-(2-phenylethyl)phenol (45%) (59JA2795). Similarly, 5-methoxybenzo[6]furan, on reduction with 2 mol of lithium and a limited amount of t- butanol, gives the cleavage product, but by operating with 2 mol each of lithium and f-butanol, 5 -methoxy-2-methylbenzo[6 jfuran supplies the 2,3-dihydro compound. With excess of the alcohol, however, 5-methoxy-2,3,4,7-tetrahydrobenzo[6]furan is secured so that the reduction is stepwise (67JOC2794). 

The introduction of electron-donating substituents into the isoxazole ring facilitates the nitration process. Thus, the nitration of 3,5-dialkylisoxazoles [168-171] or bis(3-methylisoxazolyl-5) [172] gave the corresponding 4-nitro derivatives Under the same conditions, however, 3-methyl-5-(2-methoxy-2-phenylethyl)isoxazole was only nitrated in the phenyl ring [173], Conversely, even at room temperature the nitration of 3-methyl-5-dichloromethyl- and 3-dichloromethyl-5-methylisox-azole gives the corresponding 4-nitro derivatives [174], The nitration of 3-bromo-5-methylisoxazole is similar [175]. 

The reaction between dimethyl 2-bromo-l-phenylpropylidenemalonate and sodium methoxide in methanol affords a complex reaction mixture consisting of dimethyl 2-methyl-3-phenyl-2-cyclopropene-l,l-dicarboxylate (303,19%), dimethyl (2,2-dimethoxy-l-methyl-2-phenylethyl)malonate (304, 4%), dimethyl 2-methoxy-l-phenylpropyl-idenemalonate (305, 11%), dimethyl 2-bromo-l-phenyl-1-propenylmalonate (306 -isomer, 10% Z-isomer, 13%) and dimethyl (l,2-dimethoxy-l-phenylpropyl)malonate... 

SNSj 6-Methyl-2-nitroimino2//-thiazolo[3,2-Z)][l,2,4]thiadiazole (11) <84CPB3483> NNSj 2-phenyl-5-[(4-ethoxycarbonyl)thiazol-2-yl]thiazolo[3,2-Z)][l,2,4]triazole (12) <85AX(C)1238> and AiV7V/5,6-dihydroxy-2-methoxy-4-[(l/ )-phenylethyl]-4//-imidazo[l,2-Z)][l,2,4]triazole-(55)-car-boxylic acid (13) <92TA5i>. 

A-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-2-propenamide, see A-10027 2-Hydroxy-4-methoxy-6-(2-phenylethyl)-3-prenylbenzoic acid, in D-10236... 

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