2-methoxy-2-phenylethyl

RN 34758-83-3 MF C23H32N2O3 MW 384.52. EINECS 252-191-7 CN 4-(2-methoxy-2-phenylethyl)-a-(methoxyphenylmethyl)-l-piperazineethanol... 

INSECT CONTROL TECHNOLOGY] (Vol 14) l-(2-Methoxy-2-phenylethyl)piperazme... 

Methoxy-2-phenylethyl phenyl tellurium was oxidized to the dimethyl acetal of phenylacetaldehyde by one molar-equivalent of 3-chloroperoxybenzoic acid in methanol3. 

The introduction of electron-donating substituents into the isoxazole ring facilitates the nitration process. Thus, the nitration of 3,5-dialkylisoxazoles [168-171] or bis(3-methylisoxazolyl-5) [172] gave the corresponding 4-nitro derivatives Under the same conditions, however, 3-methyl-5-(2-methoxy-2-phenylethyl)isoxazole was only nitrated in the phenyl ring [173], Conversely, even at room temperature the nitration of 3-methyl-5-dichloromethyl- and 3-dichloromethyl-5-methylisox-azole gives the corresponding 4-nitro derivatives [174], The nitration of 3-bromo-5-methylisoxazole is similar [175]. 

The preparation of 4-(2,3-dichlorophenyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-1,7-naphthyridine-3-carboxylic acid 2-methoxy-2-phenylethyl ester, (I), and other Step 5 condensation analogues of the current invention are described (2) and illustrated in Eq. 1 ... 

A carbonyl function in the a-position relative to the cyclopropane ring renders the adjacent endocyclic bond susceptible to cleavage by nucleophiles. The reactivity can be greatly increased when the polarity of the carbonyl group is enhanced by the addition of electrophiles such as protons or Lewis acids. This is exemplified by the reaction of cyclopropane dicarboxylic acid (2a) with sulfuric acid which leads to (2-hydroxyethyl)malonic acid (3a) if water is present. In a similar fashion, 2-phenylcyclopropane-l, 1-dicarboxylate (2b) gives dimethyl (2-methoxy-2-phenylethyl)malonate (3b) when treated with sulfuric acid in methanol. ... 

The phenolate anion was shown to react with diethylcyclopropane-l,l-dicarboxylate (1) to afford diethyl (2-phenoxyethyl)malonate (2) in 60% yield. Isopropylidene 2-phenylcyclopro-pane-l,l-dicarboxylate (3) reacted smoothly with methanol to give isopropylidene (2-methoxy-2-phenylethyl)malonate (4). ... 

Eprozlnol. 4-(2-Methoxy-2-phenyIethy0-a-phen-yi-l-piperaziuepropanot 1 -(2-methoxy-2-phenylethyl)-4-(3-hydroxy-3-phenylpropyOpiperazine, mol... 

Synonyms. 4-(2-Methoxy-2-phenylethyl)-a-(methoxyphenyl-methyl)-l-piperazeneethanol l-(2-Methoxy-2-phenylethyl)-4-(2-hydroxy-3-methoxy-3-phenylpropyl) piperazine. 

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