Method scope

Analytical, bioanalytical, and microbiological method scopes of work will describe the following ... 

Scientific Committee on Problems of the Environment (SCOPE), Working Group on Methodology of Determination of Toxic Substances in the Environment, Environmental Pollutants Selected Analytical Methods (SCOPE 6), Ann Arbor Science Publishers, Ann Arbor, MI, 1975. 

Where the method scope covers a range of sample matrices and/or analyte concentrations, an additional uncertainty term Rs is required to take account of differences in the recovery of a particular sample type, compared to the material used to estimate Rm. This can be evaluated by analysing a representative range of spiked samples, covering typical matrices and analyte concentrations, in replicate. The mean recovery for each sample type is calculated. Rs is normally assumed to be equal to 1. However, there will be an uncertainty associated with this assumption, which appears in the spread of mean recoveries observed for the different spiked samples. The uncertainty, u(Rs), is therefore taken as the standard deviation of the mean recoveries for each sample type. 

FIGURE 3.3 Steps in method development. A systematic approach for defining and devel oping a method is shown from the initial steps of determining the method scope to evaluation of reagents, method development, and optimization, and finally, transfer to prestudy validation. 

Establish vehicle/driver screening/inspection process for entry to site identity roles and responsibilities and methods/scope of inspection. 

Identify roles and responsibilities and methods/scope of inspection. 

It is necessary to first understand what we should expect to achieve from method validation. There are three basic considerations (1) the validation should define the method scope, which includes the analyte/matrix combinations to which the method can be applied and the concentration range within which reliable results have been demonstrated ... 

Results from these samples should be recorded continuously, and the data are used to verify that the test works reliably. The choice of analytes to include in routine QC samples should follow the same rules as those selected for the initial or abridged validation exercise, that is, the worst-case analytes that are listed in the method scope or the most relevant analytes in a national control plan. Even if the use of spiked samples as QC is applicable, it is highly preferable to use incurred samples where possible. QC samples should be stored for a period determined by the laboratory according to stability data available for the analyte/matrix. The data obtained with the QC samples should be stored and remain traceable as long as the method is used in the laboratory. The results obtained from the QC samples should be used to supplement the initial and abridged validation data. 

Al-Tabari s monumental work explores the history of the ancient nations, with special emphasis on biblical peoples and prophets, the legendary and foctual history of ancient Iran, and, in great detail, the rise of Islam, the life of the Prophet Mubanimad, and the history of the Islamic world down to the year 915. The first volume of this translation contains a biography of al-Tabari and a discussion of the method, scope, and value of his work. It also provides information on some of die technical ctxisiderations that have guided the work of the translators. 

American Association of Textile Chemists and Colorists [AATCC], 2012. AATCC Test Method 8, Colorfastness to Crocking AATCC Crockmeter Method. American Association of Textile Chemists and Colorists [AATCC]. Available at http //www.aatcc.org/tech nical/test methods/scopes/tm8.cfm (accessed 07.02.13). 

Method Scope and aim Analysis object Basic characteristics Measure of risk... 

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