Exploring the Scope and Limitation of Our Method

Entry Mono-alkoxy silane Alcohol Time (h) Silyl ketal % Isolated yield 

The mono-alkoxy product from 2-phenylethanol and diisopropylsilane (la) was used in the evaluation (Table 11). When la was treated with (+)-ethyl lactate using 10 % Pd/C as 

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Thus far we have been using (+)-ethyl lactate as the alcohol in the first step in the synthesis of silyl ketals. As we mentioned in the introduction, in order for our method to be transferred for use with high-value synthetic intermediates in a complex target-oriented synthesis, we must explore the scope and limitation of our method. We began by evaluating the synthesis of silyl ketals by reversing the order of the alcohol addition (Scheme 30). 

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