Method transfer scope changes

A significant change in scope for a transfer project may occur when the initial method transfer fails and either training of personnel at the receiving lab is required or additional method development needs to be initiated. Any additional experiments represent a change in work scope, and should be clearly spelled out and added to the method transfer plan. 

It is extremely beneficial to have a comprehensive analytical development report that provides the scope of each analytical method, chronology, rationale for changes, and equivalency or superiority of the optimized methods. Usually, the analytical development report for each method, along with the validation report, facilitates the technology transfer process. 

ABSTRACT. Laser and molecular beam techniques allow detailed study of many dynamical properties of single reactive collisions. The chemical scope of these methods is now very wide and includes internal state preparation of reactants, change of collision energies, state detection of products, and thus determination of state-to-state reaction rates. The great impact of laser spectroscopy on knowledge in the field of structure, molecular energy transfer and the mechanism of elementary chemical reactions is illustrated by two selected examples, i.e. studies in which laser-induced fluorescence (LIF) has been used to determine the specific impact parameter dependence of the Ca + HF -> CaF(X) + H reaction and the product state distributions for the reaction of metastable Ca with SF5. 

The methods for the determination of GBs and PAs (Chap. 2.12) make use of their relation to (Eq. 9.23) and the shift of upon change of [AH] or B, respectively [187,188]. Basically, the value of GB or PA is bracketed by measuring eq with a series of several reference bases ranging from lower to higher GB than the unknown. There are two methods we should address in brief, a detailed treatment of the topic being beyond the scope of the present book, however. The kinetic method makes use of the dissociation of proton-bound heterodimers, and the ther-mokinetic method determines the equilibrium constant of the acid-base reaction of gaseous ions. In general, proton transfer plays a crucial role in the formation of protonated molecules, e.g., in positive-ion chemical ionization mass spectromehy (Chap. 7). 

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